Iron supplementation enhances RSL3-induced ferroptosis to treat naïve and prevent castration-resistant prostate cancer

F Maccarinelli, D Coltrini, S Mussi, M Bugatti… - Cell Death …, 2023 - nature.com
Prostate cancer (PCa) is a leading cause of death in the male population commonly treated
with androgen deprivation therapy that often relapses as androgen-independent and …

Analysis of genetic biomarkers, polymorphisms in ADME-related genes and their impact on pharmacotherapy for prostate cancer

K Rehman, Z Iqbal, D Zhiqin, H Ayub, N Saba… - Cancer Cell …, 2023 - Springer
Prostate cancer (PCa) is a non-cutaneous malignancy in males with wide variation in
incidence rates across the globe. It is the second most reported cause of cancer death. Its …

A novel intronic circular RNA circFGFR1int2 up-regulates FGFR1 by recruiting transcriptional activators P65/FUS and suppressing miR-4687-5p to promote prostate …

R Wang, J Zhong, X Pan, Z Su, Y Xu, M Zhang… - Journal of Translational …, 2023 - Springer
Fibroblast growth factor receptor 1 (FGFR1) is a core component of the FGFs/FGFR pathway
that activates multiple signalling pathways, including ERK1/2, PI3K/AKT, PLCγ, and NF-κB …

Humanized disulfide‐stabilized diabody against fibroblast growth factor‐2 inhibits PD‐L1 expression and epithelial‐mesenchymal transition in hepatoma cells through …

H Sun, X Song, C Li, Q Li, S Liu, N Deng - IUBMB life, 2023 - Wiley Online Library
Abstract Fibroblast growth factor 2 (FGF2) plays an important role in tumor angiogenesis.
Humanized disulfide‐stable double‐chain antibody against fibroblast growth factor‐2 (anti …

Phenotypic spectrum of FGF10-related disorders: a systematic review

K Bzdega, JA Karolak - PeerJ, 2022 - peerj.com
FGF10, as an FGFR2b-specific ligand, plays a crucial role during cell proliferation, multi-
organ development, and tissue injury repair. The developmental importance of FGF10 has …

Exploring the FGF/FGFR system in ocular tumors: new insights and perspectives

A Loda, M Turati, F Semeraro, S Rezzola… - International Journal of …, 2022 - mdpi.com
Ocular tumors are a family of rare neoplasms that develop in the eye. Depending on the type
of cancer, they mainly originate from cells localized within the retina, the uvea, or the …

Angiogenesis as therapeutic target in metastatic prostate cancer–narrowing the gap between bench and bedside

AG Solimando, C Kalogirou, M Krebs - Frontiers in Immunology, 2022 - frontiersin.org
Angiogenesis in metastatic castration-resistant prostate cancer (mCRPC) has been
extensively investigated as a promising druggable biological process. Nonetheless …

Transcriptomic analysis of benign prostatic hyperplasia identifies critical pathways in prostatic overgrowth and 5‐alpha reductase inhibitor resistance

R Jin, CM Forbes, NL Miller, J Lafin, DW Strand… - The …, 2024 - Wiley Online Library
Background The medical therapy of prostatic symptoms (MTOPS) trial randomized men with
symptoms of benign prostatic hyperplasia (BPH) and followed response of treatment with a …

FGFR blockade by pemigatinib treats naïve and castration resistant prostate cancer

P Chiodelli, D Coltrini, M Turati, M Cerasuolo… - Cancer Letters, 2022 - Elsevier
Prostate cancer (PCa) is a leading cause of cancer mortality in the male population
commonly treated with androgen deprivation therapy (ADT) and relapsing as aggressive …

Incidence of FGFR2 amplification and FGFR2 fusion in patients with metastatic cancer using clinical sequencing

S Hyung, B Han, J Jung, ST Kim, JY Hong… - Journal of …, 2022 - Wiley Online Library
Aberrations in the fibroblast growth factor receptor2 (FGFR2) gene, including genetic
alterations and chromosomal rearrangements, lead to the development and progression of …