Modulators of small-and intermediate-conductance calcium-activated potassium channels and their therapeutic indications

H Wulff, A Kolski-Andreaco… - Current medicinal …, 2007 - ingentaconnect.com
Calcium-activated potassium channels modulate calcium signaling cascades and
membrane potential in both excitable and non-excitable cells. In this article we will review …

Molecular and cellular basis of small-and intermediate-conductance, calcium-activated potassium channel function in the brain

P Pedarzani, M Stocker - Cellular and Molecular Life Sciences, 2008 - Springer
Small conductance calcium-activated potassium (SK or K Ca 2) channels link intracellular
calcium transients to membrane potential changes. SK channel subtypes present different …

K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom

S Mouhat, V Visan, S Ananthakrishnan… - Biochemical …, 2005 - portlandpress.com
OSK1 (α-KTx3. 7) is a 38-residue toxin cross-linked by three disulphide bridges that was
initially isolated from the venom of the Asian scorpion Orthochirus scrobiculosus. OSK1 and …

K+ channel blockers: novel tools to inhibit T cell activation leading to specific immunosuppression

G Panyi, LD Possani, RCR De La Vega… - Current …, 2006 - ingentaconnect.com
During the last two decades since the identification and characterization of T cell potassium
channels great advances have been made in the understanding of the role of these …

Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2

VG Shakkottai, I Regaya, H Wulff, Z Fajloun… - Journal of Biological …, 2001 - ASBMB
Apamin-sensitive small conductance calcium-activated potassium channels (SKCa1–3)
mediate the slow afterhyperpolarization in neurons, but the molecular identity of the channel …

Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization …

P Pedarzani, D D'hoedt, KB Doorty… - Journal of Biological …, 2002 - ASBMB
The biophysical properties of small conductance Ca 2+-activated K+(SK) channels are well
suited to underlie afterhyperpolarizations (AHPs) shaping the firing patterns of a …

Small conductance calcium-activated potassium channels: from structure to function

KL Weatherall, SJ Goodchild, DE Jane… - Progress in …, 2010 - Elsevier
The cloning of KCa2 channels revealed three subtypes, with each displaying distinct but
partially overlapping expression distributions in the mammalian CNS and periphery …

Matching molecules to function: neuronal Ca2+-activated K+ channels and afterhyperpolarizations

M Stocker, K Hirzel, D D'hoedt, P Pedarzani - Toxicon, 2004 - Elsevier
Potassium channels regulate the membrane excitability of neurons, play a major role in
shaping action potentials, determining firing patterns and regulating neurotransmitter …

A Novel Conotoxin Inhibitor of Kv1.6 Channel and nAChR Subtypes Defines a New Superfamily of Conotoxins,

JS Imperial, PS Bansal, PF Alewood, NL Daly… - Biochemistry, 2006 - ACS Publications
Using assay-directed fractionation of the venom from the vermivorous cone snail Conus
planorbis, we isolated a new conotoxin, designated pl14a, with potent activity at both …

Scorpion toxin peptide action at the ion channel subunit level

DM Housley, GD Housley, MJ Liddell, EA Jennings - Neuropharmacology, 2017 - Elsevier
This review categorizes functionally validated actions of defined scorpion toxin (SCTX)
neuropeptides across ion channel subclasses, highlighting key trends in this rapidly …