We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

The hallmarks of cancer comprise six biological capabilities acquired during the multistep
development of human tumors. The hallmarks constitute an organizing principle for …

A number of stresses, including nutrient stress, temperature shock, DNA damage, and
hypoxia, can lead to changes in gene expression patterns caused by a general shutdown …

The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …

Blood travels throughout the body in an extensive network of vessels–arteries, veins and
capillaries. This vascular network is not static, but instead dynamically remodels in response …

Pericellular proteases have long been associated with cancer invasion and metastasis due
to their ability to degrade extracellular matrix components. Recent studies demonstrate that …

Reactive oxygen species (ROS) are closely related to tumorgenesis. Under hypoxic
environment, increased levels of ROS induce the expression of hypoxia inducible factors …

Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and
therapeutic angiogenesis, which has potential in the treatment of various cardiovascular …

Introduction‐Angiogenesis in physiology and pathology‐Angiogenesis in current medicine‐
VEGF ligand and receptor system: where does sVEGFR1 fit?‐Ligands: the human VEGF …

The vasculature of an organism has the daunting task of connecting all the organ systems to
nourish tissue and sustain life. This complex network of vessels and associated cells must …