A review of computational and mathematical modeling contributions to our understanding of Mycobacterium tuberculosis within-host infection and treatment
Tuberculosis (TB) is an ancient and deadly disease characterized by complex host-
pathogen dynamics playing out over multiple time and length scales and physiological …
pathogen dynamics playing out over multiple time and length scales and physiological …
VEGF-A splice variants bind VEGFRs with differential affinities
SB Mamer, A Wittenkeller, PI Imoukhuede - Scientific reports, 2020 - nature.com
Vascular endothelial growth factor A (VEGF-A) and its binding to VEGFRs is an important
angiogenesis regulator, especially the earliest-known isoform, VEGF-A165a. Yet several …
angiogenesis regulator, especially the earliest-known isoform, VEGF-A165a. Yet several …
Molecular oncology of breast cancer
H Joshi, MF Press - The Breast, 2018 - Elsevier
Breast cancer, like other cancers, is a genetic disease. The disease is caused by acquired
molecular alterations during the lifetime of an individual and by inherited mutant genes. Risk …
molecular alterations during the lifetime of an individual and by inherited mutant genes. Risk …
Pre-and perinatal ischemia-hypoxia, the ischemia-hypoxia response pathway, and ADHD risk
TF Smith, R Schmidt-Kastner, JE McGeary… - Behavior genetics, 2016 - Springer
This review focuses on how measured pre-and perinatal environmental and (epi) genetic
risk factors are interrelated and potentially influence one, of many, common developmental …
risk factors are interrelated and potentially influence one, of many, common developmental …
Systems biology of pro‐angiogenic therapies targeting the VEGF system
Vascular endothelial growth factor (VEGF) is a family of cytokines for which the
dysregulation of expression is involved in many diseases; for some, excess VEGF causes …
dysregulation of expression is involved in many diseases; for some, excess VEGF causes …
The molecular pathogenesis of head and neck cancer
JD Klein, JR Grandis - Cancer biology & therapy, 2010 - Taylor & Francis
Head and neck cancer arises from a series of molecular alterations progressive from
dysplasia to carcinoma in situ, and finally invasive carcinoma. Risk factors associated with …
dysplasia to carcinoma in situ, and finally invasive carcinoma. Risk factors associated with …
Inhibition of angiogenesis by IL-32: possible role in asthma
N Meyer, J Christoph, H Makrinioti, P Indermitte… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: IL-32 is a proinflammatory cytokine involved in various chronic
inflammatory diseases. Chronic airway inflammation in asthmatic patients results in …
inflammatory diseases. Chronic airway inflammation in asthmatic patients results in …
The force at the tip-modelling tension and proliferation in sprouting angiogenesis
P Santos-Oliveira, A Correia, T Rodrigues… - PLoS computational …, 2015 - journals.plos.org
Sprouting angiogenesis, where new blood vessels grow from pre-existing ones, is a
complex process where biochemical and mechanical signals regulate endothelial cell …
complex process where biochemical and mechanical signals regulate endothelial cell …
Microvascular bioengineering: a focus on pericytes
H Zhao, JC Chappell - Journal of Biological Engineering, 2019 - Springer
Capillaries within the microcirculation are essential for oxygen delivery and nutrient/waste
exchange, among other critical functions. Microvascular bioengineering approaches have …
exchange, among other critical functions. Microvascular bioengineering approaches have …
The microcirculation: physiology at the mesoscale
TW Secomb, AR Pries - The Journal of physiology, 2011 - Wiley Online Library
The microcirculation exemplifies the mesoscale in physiological systems, bridging larger
and smaller scale phenomena. Microcirculatory research represents an example of a …
and smaller scale phenomena. Microcirculatory research represents an example of a …