Animals have sophisticated mechanisms for coping with danger. Freezing is a unique state
that, upon threat detection, allows evidence to be gathered, response possibilities to be …

Cognitive deficits are now widely recognized to be an important component of anxiety. In
particular, anxiety is thought to restrict the capacity of working memory by competing with …

Recent years have witnessed the emergence of powerful new tools for assaying the brain
and a remarkable acceleration of research focused on the interplay of emotion and …

Anxiety disorders constitute a sizeable worldwide health burden with profound social and
economic consequences. The symptoms are wide-ranging; from hyperarousal to difficulties …

Efficient inhibitory control is vital. However, environmental cues can influence motor control
especially in an emotional context. One common task to measure inhibitory control is the …

Background Serious and debilitating symptoms of anxiety are the most common mental
health problem worldwide, accounting for around 5% of all adult years lived with disability in …

Threat-anticipatory defensive responses have evolved to promote survival in a dynamic
world. While inherently adaptive, aberrant expression of defensive responses to potential …

In the previous 15 years, a variety of experimental paradigms and methods have been
employed to study inhibition. In the current review, we analyze studies that have used the …

Background Anxiety patients exhibit deficits in cognitive tasks that require prefrontal control
of attention, including those that tap working memory (WM). However, it is unclear whether …

Animal models of anxiety disorders are important for elucidating neurobiological defense
mechanisms. However, animal models are limited when it comes to understanding the more …