The cholinergic hypothesis was initially presented over 20 years ago and suggests that a
dysfunction of acetylcholine containing neurons in the brain contributes substantially to the …

Given the rapid rate of population aging and the increased incidence of cognitive decline
and neurodegenerative diseases with advanced age, it is important to ascertain the …

A substantial body of literature has suggested that the memory and learning deficits
associated with Alzheimer's disease and aging are attributable to degeneration of the …

The pros and cons of estrogen therapy for use in postmenopausal women continue to be a
major topic of debate in women's health. Much of this debate focuses on the potential …

Immunocytochemical mapping studies employing the extensively used monoclonal anti-
muscarinic acetylcholine receptor (mAChR) antibody M35 are reviewed. We focus on three …

The possible relationship between behavioral arousal and acetylcholine release in the
striatum, hippocampus and frontal cortex was investigated in rats. In vivo microdialysate …

Measuring the changes in neurotransmitter extracellular levels in discrete brain areas is
considered a tool for identifying the neuronal systems involved in specific behavioral …

The ability of motor training to encode a motor memory is reduced in older adults. Here, we
tested the hypothesis that training-dependent memory encoding, an issue of relevance in …

Abstract 18 older normal volunteers (mean age= 66.5±7.9 years) and 46 younger volunteers
(mean age= 27.0±6.1 years) were administered the anticholinergic drug scopolamine (0.5 …

We review mainly recent studies on vasodilative regulation of cortex and hippocampus by
central cholinergic nerves originating in the basal forebrain. We also briefly review the …