Structural similarities and differences between the human and the mouse pancreas
Mice remain the most studied animal model in pancreas research. Since the findings of this
research are typically extrapolated to humans, it is important to understand both similarities …
research are typically extrapolated to humans, it is important to understand both similarities …
Role of TGF-beta signaling in beta cell proliferation and function in diabetes
HL Wang, L Wang, CY Zhao, HY Lan - Biomolecules, 2022 - mdpi.com
Beta (β) cell dysfunction or loss is the common pathological feature in all types of diabetes
mellitus (diabetes). Resolving the underlying mechanism may facilitate the treatment of …
mellitus (diabetes). Resolving the underlying mechanism may facilitate the treatment of …
The vascular basement membrane: a niche for insulin gene expression and β cell proliferation
G Nikolova, N Jabs, I Konstantinova, A Domogatskaya… - Developmental cell, 2006 - cell.com
Endocrine pancreatic β cells require endothelial signals for their differentiation and function.
However, the molecular basis for such signals remains unknown. Here, we show that β cells …
However, the molecular basis for such signals remains unknown. Here, we show that β cells …
Connexins: key mediators of endocrine function
D Bosco, JA Haefliger, P Meda - Physiological reviews, 2011 - journals.physiology.org
The appearance of multicellular organisms imposed the development of several
mechanisms for cell-to-cell communication, whereby different types of cells coordinate their …
mechanisms for cell-to-cell communication, whereby different types of cells coordinate their …
Biological and biomaterial approaches for improved islet transplantation
AS Narang, RI Mahato - Pharmacological reviews, 2006 - ASPET
Islet transplantation may be used to treat type I diabetes. Despite tremendous progress in
islet isolation, culture, and preservation, the clinical use of this modality of treatment is …
islet isolation, culture, and preservation, the clinical use of this modality of treatment is …
FEM-based oxygen consumption and cell viability models for avascular pancreatic islets
P Buchwald - Theoretical Biology and Medical Modelling, 2009 - Springer
Background The function and viability of cultured, transplanted, or encapsulated pancreatic
islets is often limited by hypoxia because these islets have lost their vasculature during the …
islets is often limited by hypoxia because these islets have lost their vasculature during the …
Islet vasculature as a regulator of endocrine pancreas function
N Ballian, FC Brunicardi - World journal of surgery, 2007 - Springer
The islets of Langerhans consist of endocrine cells embedded in a network of specialized
capillaries that regulate islet blood flow. Despite evidence for a critical role of islet perfusion …
capillaries that regulate islet blood flow. Despite evidence for a critical role of islet perfusion …
[HTML][HTML] Organ-specific endothelial cell heterogenicity and its impact on regenerative medicine and biomedical engineering applications
Endothelial cells (ECs) are a key cellular component of the vascular system as they form the
inner lining of the blood vessels. Recent findings highlight that ECs express extensive …
inner lining of the blood vessels. Recent findings highlight that ECs express extensive …
Pancreas islets in metabolic signaling-focus on the β-cell
J Suckale, M Solimena - Nature Precedings, 2008 - nature.com
Taken together the Islets of Langerhans form a nutrient sensing network spread throughout
the pancreas. They are tightly connected to the source organ-the intestine-and the target …
the pancreas. They are tightly connected to the source organ-the intestine-and the target …
Engineered VEGF-releasing PEG–MAL hydrogel for pancreatic islet vascularization
EA Phelps, KL Templeman, PM Thulé… - Drug delivery and …, 2015 - Springer
Biofunctionalized polyethylene glycol maleimide (PEG–MAL) hydrogels were engineered as
a platform to deliver pancreatic islets to the small bowel mesentery and promote graft …
a platform to deliver pancreatic islets to the small bowel mesentery and promote graft …