Physiology and pathophysiology of human airway mucus

DB Hill, B Button, M Rubinstein… - Physiological …, 2022 - journals.physiology.org
The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

[HTML][HTML] SERS sensing for cancer biomarker: Approaches and directions

L Vázquez-Iglesias, GMS Casagrande, D García-Lojo… - Bioactive Materials, 2024 - Elsevier
These days, cancer is thought to be more than just one illness, with several complex
subtypes that require different screening approaches. These subtypes can be distinguished …

Airway mucus in pulmonary diseases: Muco-adhesive and muco-penetrating particles to overcome the airway mucus barriers

R Pangeni, T Meng, S Poudel, D Sharma… - International journal of …, 2023 - Elsevier
Airway mucus is a complex viscoelastic gel that provides a defensive physical barrier and
shields the airway epithelium by trapping inhaled foreign pathogens and facilitating their …

Untangling mucosal drug delivery: engineering, designing, and testing nanoparticles to overcome the mucus barrier

J Watchorn, AJ Clasky, G Prakash… - ACS Biomaterials …, 2022 - ACS Publications
Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in
the human body. High vascularization and accessibility have motivated drug delivery to …

The changing landscape of the cystic fibrosis lung environment: from the perspective of Pseudomonas aeruginosa

MA Greenwald, MC Wolfgang - Current Opinion in Pharmacology, 2022 - Elsevier
This review guides the reader through the current understanding of the dynamic changes
that occur within the cystic fibrosis (CF) lung that allow Pseudomonas aeruginosa to become …

[HTML][HTML] The lung, the niche, and the microbe: Exploring the lung microbiome in cancer and immunity

M Huynh, MJ Crane, AM Jamieson - Frontiers in Immunology, 2023 - frontiersin.org
The lung is a complex and unique organ system whose biology is strongly influenced by
environmental exposure, oxygen abundance, connection to extrapulmonary systems via a …

Cystic fibrosis mucus model to design more efficient drug therapies

C Butnarasu, G Caron, DP Pacheco… - Molecular …, 2021 - ACS Publications
Mucus represents a strong barrier to tackle for oral or pulmonary administered drugs,
especially in mucus-related disorders. This study uses a pathological cystic fibrosis (CF) …

[HTML][HTML] Mucins as potential biomarkers for early detection of cancer

SK Gautam, P Khan, G Natarajan, P Atri, A Aithal… - Cancers, 2023 - mdpi.com
Simple Summary Early cancer detection is a challenge in treating cancer patients.
Remarkably, carcinomas of the breast, lung, liver, pancreas, ovary, and colon contribute to …

[HTML][HTML] Applying next-generation sequencing and multi-omics in chronic obstructive pulmonary disease

PY Tiew, OW Meldrum, SH Chotirmall - International journal of molecular …, 2023 - mdpi.com
Microbiomics have significantly advanced over the last decade, driven by the widespread
availability of next-generation sequencing (NGS) and multi-omic technologies. Integration of …

[HTML][HTML] Immunomodulatory properties of vitamin D in the intestinal and respiratory systems

FN Hamza, S Daher, HMA Fakhoury, WB Grant… - Nutrients, 2023 - mdpi.com
Vitamin D plays a crucial role in modulating the innate immune response by interacting with
its intracellular receptor, VDR. In this review, we address vitamin D/VDR signaling and how it …