Background: Fourteen clinical trials have not shown a consistent benefit of combination
therapy with levothyroxine (LT4) and liothyronine (LT3). Despite the publication of these …

A systematic review of measurement properties of health-status instruments is a tool for
evaluating the quality of instruments. Our aim was to appraise the quality of the review …

Background: A number of recent advances in our understanding of thyroid physiology may
shed light on why some patients feel unwell while taking levothyroxine monotherapy. The …

Context: Subclinical hypothyroidism (SCH) is defined as raised serum TSH levels with
circulating thyroid hormones within the reference range. It is uncertain whether treatment of …

Objectives The aim of this study was to evaluate whether subclinical thyroid disease is
associated with impaired health‐related quality of life and a more adverse cardiovascular …

Objective: Many hypothyroid subjects receiving L-thyroxine (L-T4) complain of psychological
symptoms or cognitive dysfunction. However, there is limited validated information on these …

Objectives To appraise the measurement properties of thyroid-specific health-related quality-
of-life (HRQOL) instruments and to provide recommendations on the choice of HRQOL …

Background: Until recently, treatment of hypothyroidism has been accomplished using
monotherapy of synthetic L-thyroxine (L-T4) sodium tablets that should be taken 30-60 …

Objective: The objective of the study was to determine whether subclinical hypothyroidism
causes decrements in health status, mood, and/or cognitive function. Design: This was a …

Objective: The aim was to evaluate the quality of life (HRQoL) in women with subclinical
hypothyroidism (sHT) after 16 weeks of endurance training. Subjects and methods: In the …