Cellular signaling pathways as plastic, proto-cognitive systems: Implications for biomedicine

J Mathews, AJ Chang, L Devlin, M Levin - Patterns, 2023 - cell.com
Many aspects of health and disease are modeled using the abstraction of a" pathway"—a
set of protein or other subcellular activities with specified functional linkages between them …

[HTML][HTML] The maltreated eco-phenotype of eating disorders: a new diagnostic specifier? A systematic review of the evidence and comprehensive description

E Rossi, E Cassioli, C Dani, G Marchesoni… - Neuroscience & …, 2024 - Elsevier
This systematic review aimed to summarize the evidence on the existence of a distinct
phenotypic expression of Eating Disorders (EDs) associated with childhood maltreatment …

Epigenetic changes associated with different types of stressors and suicide

G Dee, R Ryznar, C Dee - Cells, 2023 - mdpi.com
Stress is associated with various epigenetic changes. Some stress-induced epigenetic
changes are highly dynamic, whereas others are associated with lasting marks on the …

Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: a conceptual model for the study of sex and gender differences

A Donovan, S Assari, C Grella, M Shaheen… - Frontiers in …, 2024 - Elsevier
Early life stress (ELS) is defined as an acute or chronic stressor that negatively impacts a
child's development. ELS is associated with substance use and mental health problems …

Epigenetics as a biomarker for early-life environmental exposure

R Schrott, A Song, C Ladd-Acosta - Current environmental health reports, 2022 - Springer
Abstract Purpose of Review There is interest in evaluating the developmental origins of
health and disease (DOHaD) which emphasizes the role of prenatal and early-life …

[HTML][HTML] Photobiomodulation attenuates oligodendrocyte dysfunction and prevents adverse neurological consequences in a rat model of early life adversity

Z Huang, Y Zhang, X Ma, Y Feng, X Zong, JD Jordan… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: Adverse experiences in early life including abuse, trauma and neglect, have
been linked to poor physical and mental health outcomes. Emerging evidence implies that …

[HTML][HTML] The epigenome under pressure: On regulatory adaptation to chronic stress in the brain

RG Arzate-Mejia, NVN Carullo, IM Mansuy - Current Opinion in …, 2024 - Elsevier
Chronic stress (CS) can have long-lasting consequences on behavior and cognition, that
are associated with stable changes in gene expression in the brain. Recent work has …

Long‐term effects of childhood trauma subtypes on adult brain function

J Cai, J Li, D Liu, S Gao, Y Zhao, J Zhang… - Brain and …, 2023 - Wiley Online Library
Introduction Childhood trauma is prevalent in our society, whereas little is known about why
and how different forms of early traumatic experiences exert long‐term effects on differential …

In individuals with Williams syndrome, dysregulation of methylation in non-coding regions of neuronal and oligodendrocyte DNA is associated with pathology and …

SS Trangle, T Rosenberg, H Parnas, G Levy… - Molecular …, 2023 - nature.com
Williams syndrome (WS) is a neurodevelopmental disorder caused by a heterozygous micro-
deletion in the WS critical region (WSCR) and is characterized by hyper-sociability and …

Endocannabinoid signaling and epigenetics modifications in the neurobiology of stress-related disorders

AA Coelho, S Lima-Bastos, PH Gobira… - Neuronal …, 2023 - portlandpress.com
Stress exposure is associated with psychiatric conditions, such as depression, anxiety, and
post-traumatic stress disorder (PTSD). It is also a vulnerability factor to developing or …