Cellular signaling pathways as plastic, proto-cognitive systems: Implications for biomedicine
Many aspects of health and disease are modeled using the abstraction of a" pathway"—a
set of protein or other subcellular activities with specified functional linkages between them …
set of protein or other subcellular activities with specified functional linkages between them …
[HTML][HTML] The maltreated eco-phenotype of eating disorders: a new diagnostic specifier? A systematic review of the evidence and comprehensive description
This systematic review aimed to summarize the evidence on the existence of a distinct
phenotypic expression of Eating Disorders (EDs) associated with childhood maltreatment …
phenotypic expression of Eating Disorders (EDs) associated with childhood maltreatment …
Epigenetic changes associated with different types of stressors and suicide
G Dee, R Ryznar, C Dee - Cells, 2023 - mdpi.com
Stress is associated with various epigenetic changes. Some stress-induced epigenetic
changes are highly dynamic, whereas others are associated with lasting marks on the …
changes are highly dynamic, whereas others are associated with lasting marks on the …
Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: a conceptual model for the study of sex and gender differences
Early life stress (ELS) is defined as an acute or chronic stressor that negatively impacts a
child's development. ELS is associated with substance use and mental health problems …
child's development. ELS is associated with substance use and mental health problems …
Epigenetics as a biomarker for early-life environmental exposure
R Schrott, A Song, C Ladd-Acosta - Current environmental health reports, 2022 - Springer
Abstract Purpose of Review There is interest in evaluating the developmental origins of
health and disease (DOHaD) which emphasizes the role of prenatal and early-life …
health and disease (DOHaD) which emphasizes the role of prenatal and early-life …
[HTML][HTML] Photobiomodulation attenuates oligodendrocyte dysfunction and prevents adverse neurological consequences in a rat model of early life adversity
Rationale: Adverse experiences in early life including abuse, trauma and neglect, have
been linked to poor physical and mental health outcomes. Emerging evidence implies that …
been linked to poor physical and mental health outcomes. Emerging evidence implies that …
[HTML][HTML] The epigenome under pressure: On regulatory adaptation to chronic stress in the brain
Chronic stress (CS) can have long-lasting consequences on behavior and cognition, that
are associated with stable changes in gene expression in the brain. Recent work has …
are associated with stable changes in gene expression in the brain. Recent work has …
Long‐term effects of childhood trauma subtypes on adult brain function
J Cai, J Li, D Liu, S Gao, Y Zhao, J Zhang… - Brain and …, 2023 - Wiley Online Library
Introduction Childhood trauma is prevalent in our society, whereas little is known about why
and how different forms of early traumatic experiences exert long‐term effects on differential …
and how different forms of early traumatic experiences exert long‐term effects on differential …
In individuals with Williams syndrome, dysregulation of methylation in non-coding regions of neuronal and oligodendrocyte DNA is associated with pathology and …
SS Trangle, T Rosenberg, H Parnas, G Levy… - Molecular …, 2023 - nature.com
Williams syndrome (WS) is a neurodevelopmental disorder caused by a heterozygous micro-
deletion in the WS critical region (WSCR) and is characterized by hyper-sociability and …
deletion in the WS critical region (WSCR) and is characterized by hyper-sociability and …
Endocannabinoid signaling and epigenetics modifications in the neurobiology of stress-related disorders
AA Coelho, S Lima-Bastos, PH Gobira… - Neuronal …, 2023 - portlandpress.com
Stress exposure is associated with psychiatric conditions, such as depression, anxiety, and
post-traumatic stress disorder (PTSD). It is also a vulnerability factor to developing or …
post-traumatic stress disorder (PTSD). It is also a vulnerability factor to developing or …