The development and differentiation of T cells represents a long and highly coordinated, yet
flexible at some points, pathway, along which the sequential and dynamic expressions of …

Abstract Zinc-Finger (ZnF) proteins represent one of the most abundant group of proteins in
the human genome. At first characterized as DNA binding proteins, it has become …

The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the
impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown …

Abstract HELLS/LSH (Helicase, Lymphoid Specific) is a SNF2-like chromatin remodelling
protein involved in DNA methylation. Its loss-of-function in humans causes humoral …

I mmunodeficiency, c entromeric instability, and f acial anomalies (ICF) syndrome is a rare
autosomal recessive disorder characterized by DNA hypomethylation and antibody …

Rare diseases (RDs), more than 80% of which have a genetic origin, collectively affect
approximately 350 million people worldwide. Progress in next-generation sequencing …

ERCC1-XPF is a multifunctional endonuclease involved in nucleotide excision repair (NER),
interstrand cross-link (ICL) repair, and DNA double-strand break (DSB) repair. Only two …

DNA lesions that evade repair can lead to mutations that drive the development of cancer,
and cellular responses to DNA damage can trigger senescence and cell death, which are …

Purpose Immunodeficiency with centromeric instability and facial anomalies (ICF) syndrome
is a rare autosomal recessive combined immunodeficiency. The detailed immune responses …

Zinc Finger DNA‐binding domain‐containing proteins are the most populous family among
eukaryotic transcription factors. Among these, members of the BTB domain‐containing ZBTB …