Dystrophic cardiomyopathy—potential role of calcium in pathogenesis, treatment and novel therapies

VPA Johnstone, HM Viola, LC Hool - Genes, 2017 - mdpi.com
Duchenne muscular dystrophy (DMD) is caused by defects in the DMD gene and results in
progressive wasting of skeletal and cardiac muscle due to an absence of functional …

Focus on the lymphatic route to optimize drug delivery in cardiovascular medicine

N Tessier, F Moawad, N Amri, D Brambilla, C Martel - Pharmaceutics, 2021 - mdpi.com
While oral agents have been the gold standard for cardiovascular disease therapy, the new
generation of treatments is switching to other administration options that offer reduced …

Curcumin‐loaded nanoparticles effectively prevent T4‐induced oxidative stress in rat heart

P Mishra, DK Sahoo, C Mohanty… - Cell Biochemistry and …, 2024 - Wiley Online Library
In this study, we report the cardioprotective effect of the glycerol monooleate (GMO) based
nanocurcumin in both in vitro and in vivo conditions under a hyperthyroid state. The heart is …

On-demand responsive nanoplatform mediated targeting of CAFs and down-regulating mtROS-PYK2 signaling for antitumor metastasis

T Zuo, J Zhang, J Yang, R Xu, Z Hu, Z Wang… - Biomaterials …, 2021 - pubs.rsc.org
The desmoplastic tumor microenvironment (DTME), including overexpressed stromal cells
and extracellular matrix, formed the first barrier for the accumulation and penetration of …

Animal models used in the research of nanoparticles for cardiovascular diseases

C Dong, A Ma, L Shang - Journal of Nanoparticle Research, 2021 - Springer
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity worldwide.
Tremendous progress has been made in the prevention and treatment of CVD; however …

Nanotechnology-based Strategies for Molecular Imaging, Diagnosis, and Therapy of Organ Transplantation

R Sun, N Wang, S Zheng, H Wang, H Xie - Transplantation, 2024 - journals.lww.com
Organ transplantation is the preferred paradigm for patients with end-stage organ failures.
Despite unprecedented successes, complications such as immune rejection, ischemia …

[HTML][HTML] Peptides derived from high voltage-gated calcium channel β subunit reduce blood pressure in rats

HK Kim, J Jun, TW Kim, D Youn - The Korean Journal of …, 2023 - synapse.koreamed.org
The β subunits of high voltage-gated calcium channels (HGCCs) are essential for optimal
channel functions such as channel gating, activation-inactivation kinetics, and trafficking to …

[HTML][HTML] A dendronized polymer variant that facilitates safe delivery of a calcium channel antagonist to the heart

HM Viola, AA Shah, JA Kretzmann, CW Evans… - … , Biology and Medicine, 2020 - Elsevier
Therapeutic approaches for myocardial ischemia–reperfusion injury (MI) have been
ineffective due to limited bioavailability and poor specificity. We have previously shown that …

Hepatocellular uptake of cyclodextrin‐complexed curcumin during liver preservation: A feasibility study

SA Saidi, N Meurisse, I Jochmans… - … & Drug Disposition, 2018 - Wiley Online Library
The increasing demand for donor organs and the decreasing organ quality is prompting
research toward new methods to reduce ischemia reperfusion injury (IRI). Several strategies …

Voltage-dependent calcium channel β subunit-derived peptides reduce excitatory neurotransmission and arterial blood pressure

H Weon, J Jun, TW Kim, K Park, HK Kim, D Youn - Life Sciences, 2021 - Elsevier
Aims Voltage-dependent calcium channels (VDCCs) play an important role in various
physiological functions in the nervous system and the cardiovascular system. In L-, N-, P/Q …