Antibody avidity is an important parameter to evaluate immune response, being useful to
evaluate vaccine responses and helping to distinguish acute and latent infection. The …

Avidity of immunoglobulin G (IgG) is defined as its binding strength to its target antigen. As a
consequence of affinity maturation of the IgG response, avidity is maturing as well …

There is intense interest in induction and characterization of strain-transcending neutralizing
Ab against antigenically variable human pathogens. We have recently identified the human …

Antibodies against P. falciparum merozoites fix complement to inhibit blood-stage replication
in naturally-acquired and vaccine-induced immunity; however, specific targets of these …

Malaria transmission-blocking vaccines candidates based on Pfs25 and Pfs230 have
advanced to clinical studies. Exoprotein A (EPA) conjugate of Pfs25 in Alhydrogel® …

Background Malaria is a public health problem in parts of Thailand, where Plasmodium
falciparum and Plasmodium vivax are the main causes of infection. In the northwestern …

Fully synthetic glycan-based vaccines hold great potential as preventive and therapeutic
vaccines against infectious diseases as well as cancer. Here, we present a two-component …

Disordered proteins are important antigens in a range of infectious diseases. Little is known,
however, about the molecular details of recognition of disordered antigens by their cognate …

Introduction A vaccine would greatly accelerate current global efforts toward malaria
elimination. While a partially efficacious vaccine has been achieved for Plasmodium …

The development of protective vaccines against many difficult infectious pathogens will
necessitate the induction of effective antibody responses. Here we assess humoral immune …