Since their identification in 1994, cancer stem cells (CSCs) have been objects of intensive
study. Their properties and mechanisms of formation have become a major focus of current …

Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …

Intracellular accumulation of tau is a hallmark pathology in Alzheimer disease (AD) and the
related tauopathies, thus targeting tau could be promising for drug development. Proteolysis …

Protein phosphorylation regulates most aspects of cell life, whereas abnormal
phosphorylation is a cause or consequence of disease. A growing interest in developing …

HIV-1 and related viruses require co-receptors, in addition to CD4, to infect target cells. The
chemokine receptor CCR-5 (ref. 1) was recently demonstrated to be a co-receptor for …

Indolocarbazoles have been identified as novel inhibitors of protein kinase C (PKC), with Gö
6976 as one of its most potent and selective representatives. Recombinant PKC isozymes …

INTRODUCTION Insulin is secreted by pancreatic β cells in response to glucose stimulation.
Its release is controlled by the interplay of calcium and phosphoinositide signaling …

The vascular complications of diabetes mellitus have been correlated with enhanced
activation of protein kinase C (PKC). LY333531, a specific inhibitor of the β isoform of PKC …

Platelets, activated by various agonists, produce microparticles (MP) from the plasma
membrane, which are released into the extracellular space. Although the mechanism of MP …

Five-membered heterocycle derivatives with two aryl groups on adjacent positions include
several classes of natural and unnatural compounds that exhibit a variety of biological and …