Clinical outcomes in non‐small‐cell lung cancer patients with EGFR mutations: pooled analysis

L Paz‐Ares, D Soulières, I Melezínek… - Journal of cellular …, 2010 - Wiley Online Library
Introduction• Literature review‐Molecular biology of EGFR mutations‐Clinical characteristics
of NSCLC patients with EGFR mutations‐Genetic characteristics of EGFR‐mutated tumours …

Pooled analysis of clinical outcome for EGFR TKI‐treated patients with EGFR mutation‐positive NSCLC

L Paz‐Ares, D Soulieres, J Moecks… - Journal of Cellular …, 2014 - Wiley Online Library
Patients with non‐small‐cell lung cancer (NSCLC) appear to gain particular benefit from
treatment with epidermal growth factor receptor (EGFR) tyrosine‐kinase inhibitors (TKI) if …

Implications of EGFR PharmDx™ Kit for cetuximab eligibility

C Ensinger, W Sterlacci - Expert review of molecular diagnostics, 2008 - Taylor & Francis
EGF receptor (EGFR) represents an attractive target for anticancer therapies in a variety of
malignant neoplasms, including colorectal, non-small-cell lung, head and neck carcinomas …

Treatment after the failure of gefitinib in patients with advanced or recurrent non-small cell lung cancer

R Maruyama, H Wataya, T Seto, Y Ichinose - Anticancer research, 2009 - ar.iiarjournals.org
Background: The optimal treatment for patients with progressive non-small cell lung cancer
who initially show a good response to gefitinib is unclear. Patients and Methods: This study …

[HTML][HTML] 酪氨酸激酶抑制剂耐药机制及其治疗策略

J QIAO, W CHEN - ncbi.nlm.nih.gov
人类表皮生长因子受体(epidermal growth factor receptor, EGFR) 是原癌基因C-erbB1
的表达产物, 属于酪氨酸激酶生长因子受体家族成员之一, 在人类多种实体肿瘤中过度表达 …

[HTML][HTML] A population-based study of gefitinib in patients with postoperative recurrent non-small cell lung cancer

K Furukawa, J Ishida, M Inagaki… - Experimental and …, 2012 - spandidos-publications.com
There is no standard treatment and there are no clearly defined guidelines for the treatment
of postoperative recurrent non-small-cell lung cancer (NSCLC). We performed a …

Effectiveness of erlotinib against recurrent pulmonary adenocarcinoma unresponsive to gefitinib: report of a case

F Shoji, D Kawano, K Ito, Y Morodomi, T Yano… - Surgery today, 2011 - Springer
We report a case of recurrent pulmonary adenocarcinoma, found 2 years after resection,
which responded extremely well to erlotinib, after gefitinib treatment had failed to evoke any …

[HTML][HTML] Initial Progression-Free Survival after Non-First Line TKIs Therapy Potentially Guides Immediate Treatment after Its Failure in Advanced Non-Small Cell Lung …

F Wang, G Guo, H Qiu, W He, F Zhou… - Cancer Biology & …, 2012 - ncbi.nlm.nih.gov
Objective The standard therapy after failure of the initial non-first line epidermal growth factor
receptor tyrosine kinase inhibitor (EGFR-TKI) treatment in advanced non-small cell lung …

Resistant Mechanism and Treatment Strategy of Tyrosine Kinase Inhibitors

Q Jianbing, C Wenping - Zhongguo Fei Ai Za Zhi, 2011 - search.proquest.com
人类表皮生长因子受体 (epiderma l growth factor receptor, EGFR) 是原癌基因 C-erbB1
的表达产物, 属于酪氨酸激酶生长因子受体家族成员之一, 在人类多种实体肿瘤中过度表达 …

[引用][C] 吉非替尼合成路线图解

李美松, 尚海萍 - 中国医药工业杂志, 2011