Role of pyroptosis, a pro-inflammatory programmed cell death, in epilepsy

R Atabaki, H Khaleghzadeh-Ahangar… - Cellular and Molecular …, 2023 - Springer
Epilepsy is one of the most common serious brain diseases worldwide. Programmed cell
death (PCD), a cellular self-destruction phenomenon, has been greatly documented in …

Long non-coding RNAs and microRNAs as crucial regulators in cardio-oncology

SB Nukala, J Jousma, Y Cho, WH Lee, SG Ong - Cell & Bioscience, 2022 - Springer
Cancer is one of the leading causes of morbidity and mortality worldwide. Significant
improvements in the modern era of anticancer therapeutic strategies have increased the …

GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome

Z Qin, J Song, A Lin, W Yang, W Zhang… - Journal of …, 2022 - Springer
Background The complex pathophysiology of epilepsy hampers the development of effective
treatments. Although more than ten kinds of anti-seizures drugs (ASDs) have good effects on …

[HTML][HTML] CircHIPK3 promotes neuroinflammation through regulation of the miR-124-3p/STAT3/NLRP3 signaling pathway in Parkinson's disease

YJ Zhang, WK Zhu, FY Qi… - Advances in Clinical and …, 2023 - advances.umw.edu.pl
Background. Parkinson's disease (PD) is characterized as a neurodegenerative disease;
however, the mechanisms regarding its pathogenesis have not been fully explored …

Neuronal nitric oxide synthase/reactive oxygen species pathway is involved in apoptosis and pyroptosis in epilepsy

XX Xu, RX Shi, Y Fu, JL Wang, X Tong… - Neural Regeneration …, 2023 - journals.lww.com
Dysfunction of neuronal nitric oxide synthase contributes to neurotoxicity, which triggers cell
death in various neuropathological diseases, including epilepsy. Studies have shown that …

Research progress on oxidative stress regulating different types of neuronal death caused by epileptic seizures

H Sun, X Li, Q Guo, S Liu - Neurological Sciences, 2022 - Springer
Clinical and experimental data hints that prolonged and repeated epileptic seizures can
lead to molecular, biochemical, metabolic, and structural changes in the brain, a continuous …

Suppression of NLRP3 Inflammasome by Dihydroarteannuin via the HIF‐1α and JAK3/STAT3 Signaling Pathway Contributes to Attenuation of Collagen-Induced …

M Zhang, D Wu, J Xu, L Liu, W Jiao, J Yu… - Frontiers in …, 2022 - frontiersin.org
Dihydroarteannuin (DHA), the primary element of artemisinin extracted from the traditional
Chinese herb Artemisia annua L., has been used in malaria treatment for a long time …

The NLRP3 inflammasome in neurodegenerative disorders: insights from epileptic models

L Palumbo, M Carinci, A Guarino, L Asth, S Zucchini… - Biomedicines, 2023 - mdpi.com
Neuroinflammation represents a dynamic process of defense and protection against the
harmful action of infectious agents or other detrimental stimuli in the central nervous system …

Role of GSDM family members in airway epithelial cells of lung diseases: a systematic and comprehensive transcriptomic analysis

X Liu, L Zhang, B Zhu, Y Liu, L Li, J Hou, M Qian… - Cell Biology and …, 2023 - Springer
Gasdermin (GSDM) family, the key executioners of pyroptosis, play crucial roles in anti-
pathogen and anti-tumor immunities, although little is known about the expression of GSDM …

miR-98-5p prevents hippocampal neurons from oxidative stress and apoptosis by targeting STAT3 in epilepsy in vitro

Z Guo, W Zhong, Z Zou - Neuropsychiatric Disease and Treatment, 2023 - Taylor & Francis
Purpose Epilepsy is a serious mental disease, for which oxidative stress and hippocampal
neuron death after seizure is crucial. Numerous miRNAs are involved in epilepsy. However …