Osteoclasts are derived from mononuclear hematopoietic myeloid lineage cells, which are
formed in the bone marrow and are attracted to the bloodstream by factors, including …

Osteoclasts are multinucleated cells formed mainly on bone surfaces in response to
cytokines by fusion of bone marrow-derived myeloid lineage precursors that circulate in the …

It is well-established that receptor activator of NF-κB ligand (RANKL) is the inducer of
physiological osteoclast differentiation. However, the specific drivers and mechanisms …

Immunglobulin G (IgG) sialylation represents a key checkpoint that determines the
engagement of pro-or anti-inflammatory Fcγ receptors (FcγR) and the direction of the …

The Notch signaling pathway is conserved from Drosophila to mammals and is critically
involved in developmental processes. In the immune system, it has been established that …

Chronic inflammatory processes close to bone often lead to loss of bone in diseases such as
rheumatoid arthritis, periodontitis, loosened joint prosthesis and tooth implants. This is …

Bone is a mineralized and elastic connective tissue that provides fundamental functions in
the human body, including mechanical support to the muscles and joints, protection of vital …

Osteoporosis (OP) affects millions worldwide but currently cannot be cured. Suppressing the
level of miR-214 in osteoclasts by the anti-miRNA oligonucleotide (AMO) anti-miR-214 …

Periodontitis and other bone loss diseases, decreasing bone volume and strength, have a
significant impact on millions of people with the risk of tooth loss and bone fracture. The …

The term osteoimmunology describes an interdisciplinary research field that links the
investigation of osteology (bone cells) with immunology. The crosstalk between innate and …