Hippocampal sclerosis (HS) is a common pathology encountered in mesial temporal lobe
epilepsy (MTLE) as well as other epilepsy syndromes and in both surgical and post‐mortem …

Hippocampal neurogenesis continues throughout life and has been suggested to play an
essential role in maintaining spatial cognitive function under physiological conditions. An …

Key points A key mechanistic concept in epilepsy is the dentate gate hypothesis, which
argues that the dentate gyrus protects hippocampal circuits from overexcitation and that a …

The phosphatidylinositol-3-kinase/phosphatase and tensin homolog (PTEN)-mammalian
target of rapamycin (mTOR) pathway regulates a variety of neuronal functions, including cell …

The hippocampus is one of the earliest affected brain regions in Alzheimer's disease (AD)
and its dysfunction is believed to underlie the core feature of the disease-memory …

Ischemic lesions stimulate adult neurogenesis in the dentate gyrus, however, this is not
associated with better cognitive function. Furthermore, increased neurogenesis is …

The sparse activity of hippocampal dentate gyrus (DG) granule cells (GCs) is thought to be
critical for cognition and behavior, whereas excessive DG activity may contribute to …

This article describes the recent advances in epileptogenesis and novel therapeutic
approaches for the prevention of epilepsy, with a special emphasis on the pharmacological …

Mesial temporal lobe epilepsy (MTLE) caused by hippocampal sclerosis is one of the most
frequent focal epilepsies in adults. It is characterized by focal seizures that begin in the …

Damage to the hippocampus can occur through many causes including head trauma,
ischemia, stroke, status epilepticus, and Alzheimer's disease. Certain changes such as …