Hippocampal dentate granule cells are among the few neuronal cell types generated
throughout adult life in mammals. In the normal brain, new granule cells are generated from …

Granule cell dispersion (GCD) is a common pathological feature observed in the
hippocampus of patients with Mesial Temporal Lobe Epilepsy (MTLE). Pathomechanisms …

A number of cellular systems work in concert to modulate nociceptive processing in the
periphery, but the mechanisms that regulate neonatal nociception may be distinct compared …

Dysregulation of the mTOR-signaling pathway is implicated in the development of temporal
lobe epilepsy. In mice, deletion of PTEN from hippocampal dentate granule cells leads to …

Objective The maturation of adult‐born granule cells and their functional integration into the
network is thought to play a key role in the proper functioning of the dentate gyrus. In …

Background: In humans, early pathological activity on invasive electrocorticograms (ECoGs)
and its putative association with pathomorphology in the early period of traumatic brain …

Mild traumatic brain injury (mTBI) disrupts hippocampal function and can lead to long-lasting
episodic memory impairments. The encoding of episodic memories relies on spatial …

Neuronal nitric oxide synthase (nNOS), the major nitric oxide synthase isoform in the
mammalian brain, is implicated in the pathophysiology of several neurological conditions …

Abnormal hippocampal granule cells are present in patients with temporal lobe epilepsy,
and are a prominent feature of most animal models of the disease. These abnormal cells are …

It has been showed that enriched environment (EE) enhances the hippocampal
neurogenesis and improves the cognitive impairments, accompanied by the increased …