Targeting ARID1A mutations in cancer
J Mullen, S Kato, JK Sicklick, R Kurzrock - Cancer treatment reviews, 2021 - Elsevier
Genes encoding SWI/SNF chromatin remodeling complex subunits are collectively mutated
in approximately 20% of human cancers. ARID1A is a SWI/SNF subunit gene whose protein …
in approximately 20% of human cancers. ARID1A is a SWI/SNF subunit gene whose protein …
Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma
Head and neck squamous cell carcinoma (HNSCC) includes a subset of cancers driven by
human papillomavirus (HPV). Here we use single-cell RNA-seq to profile both HPV-positive …
human papillomavirus (HPV). Here we use single-cell RNA-seq to profile both HPV-positive …
Phase II evaluation of aggressive dose de-escalation for adjuvant chemoradiotherapy in human papillomavirus–associated oropharynx squamous cell carcinoma
PURPOSE The purpose of this study was to determine if dose de-escalation from 60 to 66
Gy to 30 to 36 Gy of adjuvant radiotherapy (RT) for selected patients with human …
Gy to 30 to 36 Gy of adjuvant radiotherapy (RT) for selected patients with human …
Do or die: HPV E5, E6 and E7 in cell death evasion
Human papillomaviruses (HPVs) infect the dividing cells of human epithelia and hijack the
cellular replication machinery to ensure their own propagation. In the effort to adapt the cell …
cellular replication machinery to ensure their own propagation. In the effort to adapt the cell …
Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1—NFκB—IL-6 signalling axis
EL Morgan, A Macdonald - PLoS pathogens, 2019 - journals.plos.org
Persistent human papillomavirus (HPV) infection is the leading cause of cervical cancer.
Although the fundamental link between HPV infection and oncogenesis is established, the …
Although the fundamental link between HPV infection and oncogenesis is established, the …
The intersection of HPV epidemiology, genomics and mechanistic studies of HPV-mediated carcinogenesis
Of the~ 60 human papillomavirus (HPV) genotypes that infect the cervicovaginal epithelium,
only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 …
only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 …
Pembrolizumab in vaginal and vulvar squamous cell carcinoma: a case series from a phase II basket trial
JA How, AA Jazaeri, PT Soliman, ND Fleming… - Scientific reports, 2021 - nature.com
Vaginal and vulvar squamous cell carcinoma (SCC) are rare tumors that can be challenging
to treat in the recurrent or metastatic setting. We present a case series of patients with …
to treat in the recurrent or metastatic setting. We present a case series of patients with …
Actin dynamics in host–pathogen interaction
TEB Stradal, M Schelhaas - FEBS letters, 2018 - Wiley Online Library
The actin cytoskeleton and Rho GTP ase signaling to actin assembly are prime targets of
bacterial and viral pathogens, simply because actin is involved in all motile and membrane …
bacterial and viral pathogens, simply because actin is involved in all motile and membrane …
Identification of potential driver genes based on multi-genomic data in cervical cancer
Y Xu, H Luo, Q Hu, H Zhu - Frontiers in Genetics, 2021 - frontiersin.org
Background: Cervical cancer became the third most common cancer among women, and
genome characterization of cervical cancer patients has revealed the extensive complexity …
genome characterization of cervical cancer patients has revealed the extensive complexity …
The role of HLA-G in human papillomavirus infections and cervical carcinogenesis
HH Xu, WH Yan, A Lin - Frontiers in immunology, 2020 - frontiersin.org
Human leukocyte antigen (HLA)-G, a non-classical HLA-class I molecule, has a low
polymorphism frequency, restricted tissue distribution and immunoinhibitory property. HLA-G …
polymorphism frequency, restricted tissue distribution and immunoinhibitory property. HLA-G …