Rod-like CuO nanoparticles/waste masks carbon modified glassy carbon electrode as a voltammetric nanosensor for the sensitive determination of anti-cancer drug …

S Bilge, B Dogan-Topal, EB Atici, A Sınağ… - Sensors and Actuators B …, 2021 - Elsevier
In the present work, the first voltammetric method is developed for the detection of
pazopanib (PZB), a pharmaceutically active ingredient belonging to the tyrosine kinase …

Primary resistance to nivolumab plus ipilimumab therapy in patients with metastatic renal cell carcinoma

K Numakura, Y Sekine, S Hatakeyama, Y Muto… - Cancer …, 2023 - Wiley Online Library
Background Nivolumab plus ipilimumab (NIVO+ IPI) is the first‐line treatment for patients
with metastatic renal cell carcinoma (mRCC). Approximately 40% of patients achieve a …

Comprehensive assessments of immuno‐oncology drug‐based combination therapies as first‐line treatment for advanced renal cell carcinoma

K Harada, H Miyake, J Furukawa… - … Journal of Urology, 2022 - Wiley Online Library
Over the last decade, there have been substantial progress in the field of systemic therapy
for advanced renal cell carcinoma. Through the transition from treatment with cytokines to …

Real-world effectiveness of nivolumab plus ipilimumab and second-line therapy in Japanese untreated patients with metastatic renal cell carcinoma: 2-year analysis …

T Kojima, R Kato, T Sazuka… - Japanese Journal of …, 2022 - academic.oup.com
Background Nivolumab plus ipilimumab combination therapy is one of the standard
therapies for untreated renal cell carcinoma patients with an International Metastatic Renal …

Prognostic outcomes in patients with metastatic renal cell carcinoma receiving second‐line treatment with tyrosine kinase inhibitor following first‐line immune …

Y Matsushita, T Kojima, T Osawa… - … Journal of Urology, 2024 - Wiley Online Library
Objectives This study aimed to assess the prognostic outcomes in mRCC patients receiving
second‐line TKI following first‐line IO combination therapy. Methods This study …

External validation of the REMARCC model for the selection of cytoreductive nephrectomy in patients with primary metastatic renal cell carcinoma: a multicenter …

K Okita, S Hatakeyama, S Naito, K Numakura… - … Oncology: Seminars and …, 2021 - Elsevier
Objectives This study aims to evaluate the utility of the scoring system of the Registry for
Metastatic Renal Cell Carcinoma (REMARCC) model on the overall survival (OS) of patients …

Real-world outcomes of nivolumab plus ipilimumab combination therapy for advanced renal cell carcinoma in Japanese patients: data with a minimum of 3 years of …

H Ishihara, N Yuki, R Ishiyama, T Ikeda… - Japanese Journal of …, 2024 - academic.oup.com
Background Long-term follow-up data regarding treatment outcomes of nivolumab plus
ipilimumab combination therapy for advanced renal cell carcinoma as a first-line therapy are …

The lymphocyte-to-monocyte ratio as a significant inflammatory marker associated with survival of patients with metastatic renal cell carcinoma treated using …

K Numakura, Y Sekine, T Osawa, S Naito… - International Journal of …, 2024 - Springer
Background Nivolumab plus ipilimumab (NIVO+ IPI) is the first-line treatment for patients
with metastatic renal cell carcinoma (mRCC). While approximately 40% of patients treated …

The safety profile of nivolumab plus ipilimumab combination therapy in Japanese patients with renal cell carcinoma: results from post-marketing surveillance

H Uemura, N Shinohara, Y Tomita… - Japanese Journal of …, 2023 - academic.oup.com
Background Nivolumab and ipilimumab combination therapy is approved in Japan for
unresectable or metastatic renal cell carcinoma. Because the clinical trials supporting the …

The impact of eligibility for maintenance immunotherapy on prognosis in patients with unresectable or metastatic urothelial carcinoma

K Ozaki, S Hatakeyama, T Tanaka, D Noro… - BJUI …, 2022 - Wiley Online Library
Objectives To investigate the eligibility for maintenance immunotherapy and its impact on
the prognosis of advanced urothelial carcinoma treated with first‐line chemotherapy, as the …