Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

There are multiple reasons why the next generation of biological and medical studies
require increasing numbers of samples. Biological systems are dynamic, and the effect of a …

Protein glycosylation, a complex and heterogeneous post-translational modification that is
frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a …

Background & Aims There is a need for accurate biomarkers of fibrosis for population
screening of alcohol-related and non-alcoholic fatty liver disease (ALD, NAFLD). We …

Drug discovery and development affects various aspects of human health and dramatically
impacts the pharmaceutical market. However, investments in a new drug often go …

The incorporation of machine learning methods into proteomics workflows improves the
identification of disease-relevant biomarkers and biological pathways. However, machine …

Non-alcoholic fatty liver disease (NAFLD) is a common, progressive liver disease strongly
associated with the metabolic syndrome. It is unclear how progression of NAFLD towards …

Alcoholic liver injury (ALI) is the leading cause of serious liver disease, whereas current
treatments are mostly supportive and unable to metabolize alcohol directly. Here we report a …

Mass spectrometry (MS)-based blood proteomics is a crucial research focus in identifying
disease biomarkers. Blood serum or plasma is the most commonly used sample for such …

White adipose tissue (WAT) is important for metabolic homeostasis. We established the
differential proteomic signatures of WAT in glucose-tolerant lean and obese individuals and …