Designing microbial cell factories for the production of chemicals

JS Cho, GB Kim, H Eun, CW Moon, SY Lee - Jacs Au, 2022 - ACS Publications
The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …

[HTML][HTML] Synthetic biology strategies for microbial biosynthesis of plant natural products

A Cravens, J Payne, CD Smolke - Nature communications, 2019 - nature.com
Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes
to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically …

[HTML][HTML] CRISPR-Cpf1 assisted genome editing of Corynebacterium glutamicum

Y Jiang, F Qian, J Yang, Y Liu, F Dong, C Xu… - Nature …, 2017 - nature.com
Corynebacterium glutamicum is an important industrial metabolite producer that is difficult to
genetically engineer. Although the Streptococcus pyogenes (Sp) CRISPR-Cas9 system has …

Metabolic engineering advances and prospects for amino acid production

VF Wendisch - Metabolic engineering, 2020 - Elsevier
Amino acid fermentation is one of the major pillars of industrial biotechnology. The multi-
billion USD amino acid market is rising steadily and is diversifying. Metabolic engineering is …

Amino acids production focusing on fermentation technologies–A review

M D'Este, M Alvarado-Morales, I Angelidaki - Biotechnology advances, 2018 - Elsevier
Amino acids are attractive and promising biochemicals with market capacity requirements
constantly increasing. Their applicability ranges from animal feed additives, flavour …

Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being

S Wolf, J Becker, Y Tsuge, H Kawaguchi… - Essays in …, 2021 - portlandpress.com
The soil microbe Corynebacterium glutamicum is a leading workhorse in industrial
biotechnology and has become famous for its power to synthetise amino acids and a range …

[HTML][HTML] Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications

B Wiltschi, T Cernava, A Dennig, MG Casas… - Biotechnology …, 2020 - Elsevier
Competitive sustainable production in industry demands new and better biocatalysts,
optimized bioprocesses and cost-effective product recovery. Our review sheds light on the …

[HTML][HTML] Microbial production of ectoine and hydroxyectoine as high-value chemicals

M Liu, H Liu, M Shi, M Jiang, L Li, Y Zheng - Microbial Cell Factories, 2021 - Springer
Ectoine and hydroxyectoine as typical representatives of compatible solutes are not only
essential for extremophiles to survive in extreme environments, but also widely used in …

Biosystem design of Corynebacterium glutamicum for bioproduction

J Zha, Z Zhao, Z Xiao, T Eng, A Mukhopadhyay… - Current Opinion in …, 2023 - Elsevier
Highlights•Corynebacterium glutamicum has been used for many applications beyond
amino acids.•Economical, high-quality genome assemblies foster development of non-type …

[HTML][HTML] The role of the human microbiome in the pathogenesis of pain

K Ustianowska, Ł Ustianowski, F Machaj… - International Journal of …, 2022 - mdpi.com
Understanding of the gut microbiome's role in human physiology developed rapidly in recent
years. Moreover, any alteration of this microenvironment could lead to a pathophysiological …