[HTML][HTML] Genetics of multiple endocrine neoplasia type 1 syndrome: what's new and what's old

A Falchetti - F1000Research, 2017 - ncbi.nlm.nih.gov
Despite its identification in 1997, the functions of the MEN1 gene—the main gene underlying
multiple endocrine neoplasia type 1 syndrome—are not yet fully understood. In addition …

[HTML][HTML] 15 years of paraganglioma: imaging and imaging-based treatment of pheochromocytoma and paraganglioma

F Castinetti, A Kroiss, R Kumar… - Endocrine-related …, 2015 - erc.bioscientifica.com
Although anatomic imaging to assess the precise localization of pheochromocytomas/
paragangliomas (PHEOs/PGLs) is unavoidable before any surgical intervention on these …

Multiple endocrine neoplasia syndrome type 1: institution, management, and data analysis of a nationwide multicenter patient database

F Giusti, L Cianferotti, F Boaretto, F Cetani, F Cioppi… - Endocrine, 2017 - Springer
Objective The aim of this study was to integrate European epidemiological data on patients
with multiple endocrine neoplasia type 1 by creating an Italian registry of this syndrome …

Long-term natural course of small nonfunctional pancreatic neuroendocrine tumors in MEN1—results from the Dutch MEN1 Study Group

CRC Pieterman, JM De Laat, JWR Twisk… - The Journal of …, 2017 - academic.oup.com
Background Pancreatic neuroendocrine tumors (pNETs) are highly prevalent in patients with
multiple endocrine neoplasia type 1 (MEN1), and metastatic disease is an important cause …

Genetic and clinical features of multiple endocrine neoplasia types 1 and 2

C Romei, E Pardi, F Cetani, R Elisei - Journal of oncology, 2012 - Wiley Online Library
Multiple endocrine neoplasia (MEN) are clinical inherited syndromes affecting different
endocrine glands. Three different patterns of MEN syndromes can occur (MEN 1, MEN 2A …

[HTML][HTML] Phenotypes associated with MEN1 syndrome: a focus on genotype-phenotype correlations

C Mele, M Mencarelli, M Caputo, S Mai… - Frontiers in …, 2020 - frontiersin.org
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant inherited tumor
syndrome, associated with parathyroid, pituitary, and gastro-entero-pancreatic (GEP) …

MEN1, MEN4, and carney complex: pathology and molecular genetics

MH Schernthaner-Reiter, G Trivellin… - Neuroendocrinology, 2016 - karger.com
Pituitary adenomas are a common feature of a subset of endocrine neoplasia syndromes,
which have otherwise highly variable disease manifestations. We provide here a review of …

Multiple endocrine neoplasia type 1

F Giusti, F Marini, F Tonelli, ML Brandi - Principles of bone biology, 2020 - Elsevier
Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited syndrome caused by
inactivating heterozygote mutations of the MEN1 gene affecting parathyroid glands …

Twenty years of menin: emerging opportunities for restoration of transcriptional regulation in MEN1

KMA Dreijerink, HTM Timmers… - Endocrine-related …, 2017 - erc.bioscientifica.com
Since the discovery of the multiple endocrine neoplasia type 1 (MEN1) gene in 1997,
elucidation of the molecular function of its protein product, menin, has been a challenge …

Higher risk of aggressive pancreatic neuroendocrine tumors in MEN1 patients with MEN1 mutations affecting the CHES1 interacting MENIN domain

DK Bartsch, EP Slater, M Albers… - The Journal of …, 2014 - academic.oup.com
Context: Sixty to 80% of multiple endocrine neoplasia type 1 (MEN1) patients develop
pancreatic neuroendocrine neoplasias (pNENs), which reveal an aggressive behavior in …