The recommendations listed in this document are, whenever possible, evidence based.
Writing group members performed these relevant supplemental literature searches with key …

Occlusive arterial disease is a leading cause of morbidity and mortality worldwide. Aside
from balloon angioplasty, bypass graft surgery is the most commonly performed …

Whenever possible, the recommendations listed in this document are evidence based.
Articles reviewed in this guideline revision covered evidence from the past 10 years through …

Statins are an effective treatment for the prevention of cardiovascular diseases and used
extensively worldwide. However, myotoxicity induced by statins is a common adverse event …

Bypass surgery is one of the most frequently used strategies to revascularize tissues
downstream occlusive atherosclerotic lesions. For venous bypass surgery the great …

Despite a technically perfect procedure, surgical stress can determine the success or failure
of an operation. Surgical trauma is often referred to as the “neglected step-child” of global …

Cerebral ischemia occurs when blood flow to the brain is insufficient to meet metabolic
demand. This can result from cerebral artery occlusion that interrupts blood flow, limits CNS …

In clinical practice 5–10% of patients receiving statins develop myopathy, a side effect that
had been systematically underestimated in the randomized controlled trials with statins. The …

BACKGROUND: Current guidelines recommend statin therapy after coronary artery bypass
grafting (CABG) to attain low-density lipoprotein (LDL) levels less than 100 mg/dL. Whether …

Statins have demonstrated substantial benefits in supporting cardiovascular health. Older
individuals are more likely to experience the well-known muscle-related side effects of …