Simple Summary Nephrotoxicity is the dose-limiting factor of cisplatin treatment.
Nephrotoxicity is characterized by reduced kidney function. Although an often-reversible …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a vital transcription factor and its induction
is of significant importance for protecting against oxidative damage. Increased levels of …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

Cisplatin is a platinum-based chemotherapeutic that has long since been effective against a
variety of solid-cancers, substantially improving the five-year survival rates for cancer …

Cisplatin, or DDP, is a highly successful and well-known chemotherapy drug used to treat
cancer. Acquired resistance to chemotherapy is a major clinical concern, yet the …

Cisplatin (CIS)-induced testicular injury is a major obstacle in its application as
antineoplastic agent. In this study, we investigated the protective effect and mechanism of …

Chronic kidney disease (CKD) is associated with a variety of distinct disease processes that
permanently change the function and structure of the kidney across months or years. CKD is …

Nephropathy can occur following exposure of the kidneys to oxidative stress. Oxidative
stress is the result of reactive oxygen species (ROS) formation due to intracellular …

An increasing number of studies have reported the effects of curcumin (Cur) and
docosahexaenoic acid (DHA) on alleviating acute kidney injury (AKI). In this work, we have …

Osteoarthritis (OA) is a chronic and complicated degenerative disease for which there is
currently no effective treatment. Isoorientin (ISO) is a natural plant extract that has …