[HTML][HTML] Crystal forms in pharmaceutical applications: olanzapine, a gift to crystal chemistry that keeps on giving

SM Reutzel-Edens, RM Bhardwaj - IUCrJ, 2020 - journals.iucr.org
This contribution reviews the efforts of many scientists around the world to discover and
structurally characterize olanzapine crystal forms, clearing up inconsistencies in the …

Quantification of febuxostat polymorphs using powder X-ray diffraction technique

J Qiu, G Li, Y Sheng, M Zhu - Journal of pharmaceutical and biomedical …, 2015 - Elsevier
Febuxostat is a pharmaceutical compound with more than 20 polymorphs of which form A is
most widely used and usually exists in a mixed polymorphic form with form G. In the present …

l-Glutamic Acid Polymorph Control Using Amino Acid Additives

Y Mo, L Dang, H Wei - Industrial & engineering chemistry …, 2011 - ACS Publications
Additive is an effective factor in controlling crystallization of polymorph. l-Tryptophan, l-
leucine, l-threonine, l-histidine, l-alanine, and l-valine, as additives during l-glutamic acid …

Formulation of olanzapine nanosuspension based orally disintegrating tablets (ODT); comparative evaluation of lyophilization and electrospraying process as …

N Anup, S Thakkar, M Misra - Advanced Powder Technology, 2018 - Elsevier
Olanzapine (OLAN) as an antipsychotic agent has shown its potential in effective
management of psychotic disorders however its use is limited because of its poor water …

Quantitative analysis of binary polymorphs mixtures of fusidic acid by diffuse reflectance FTIR spectroscopy, diffuse reflectance FT-NIR spectroscopy, Raman …

C Guo, X Luo, X Zhou, B Shi, J Wang, J Zhao… - … of Pharmaceutical and …, 2017 - Elsevier
Vibrational spectroscopic techniques such as infrared, near-infrared and Raman
spectroscopy have become popular in detecting and quantifying polymorphism of …

A crystalline solid adduct of sulfathiazole–amantadine: the first dual-drug molecular salt containing both antiviral and antibacterial ingredients

LY Wang, YM Yu, MC Yu, YT Li, ZY Wu, CW Yan - CrystEngComm, 2020 - pubs.rsc.org
The first molecular salt concurrently combining an antibacterial drug, sulfathiazole (SFZ),
and an antiviral constituent, amantadine (ATD), was designed and successfully synthesized …

NMR Longitudinal Rotating Frame Relaxation Time (T) with a Weak Spin Locking Field as an Approach to Characterize Solid-State Active Pharmaceutical …

LS Almeida, RHS Garcia, J Ticona, SL Cuffini… - Analytical …, 2024 - ACS Publications
Nuclear magnetic resonance (NMR) longitudinal rotating frame relaxation time (T1ρ), rarely
used in low-field NMR, can be more effective than conventional T1 and T2 relaxation times …

Rational crystal polymorph design of olanzapine

H Luo, X Hao, Y Gong, J Zhou, X He… - Crystal Growth & Design, 2019 - ACS Publications
Polymorphism refers to the phenomenon that crystals of the same chemical composition can
crystallize into several different forms with different physicochemical conditions. Studying the …

Thermoanalytical investigation of olanzapine compatibility with excipients used in solid oral dosage forms

MJ Peres-Filho, MPN Gaeti, SR de Oliveira… - Journal of thermal …, 2011 - akjournals.com
During preformulation studies of pharmaceutical solid dosage forms, thermal analysis
techniques are very useful to detect physical or chemical incompatibilities between the drug …

Identification and quantification techniques of polymorphic forms-A review

JT Chambi, C Fandaruff, SL Cuffini - Journal of Pharmaceutical and …, 2024 - Elsevier
In the pharmaceutical industry, the unexpected appearance of crystalline forms could impact
the therapeutic efficacy of an Active Pharmaceutical Ingredient (API). For quality control, a …