Olanzapine (OLZ) is a commonly antipsychotic used to treat schizophrenia, a mental illness,
with fewer side effects when compared with other drugs of the same class. It is …

With as high as 60% of drugs in company pipelines exhibiting poor aqueous solubility, the
ability to successfully develop a poorly water-soluble drug has become essential. Gaining a …

Excipients can cause a considerable challenge when developing a solid form of an active
pharmaceutical ingredient (API). The aim of this present study was to analyze the …

A comprehensive study on the quantification of sulfathiazole polymorphs by near infrared
(NIR) spectroscopy combined with multivariate analysis is reported. Calibration models were …

Background: The treatment of schizophrenia typically involves the use of olanzapine (OLZ),
a typical antipsychotic drug that has poor oral bioavailability due to its low solubility and first …

Background: Milling and mixing are unit operations that are often employed in drug
formulation. Objective: This study aims at investigating the physicochemical and release …

Polimorfismo é a propriedade de moléculas cristalizarem em mais de uma forma cristalina,
o que pode afetar suas propriedades físico-químicas. Esse fenômeno está presente também …

ASP3026 (N-{2-Methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl] phenyl}-N′-[2-
(propane-2-sulfonyl) phenyl]-1, 3, 5-triazine-2, 4-diamine) was developed as a novel and …

Particle size reducing methods demand high energy input, so during these procedures
crystallinity change always can occur. These changes can be enhanced by additives, which …