Microglial phagocytosis of neurons in neurodegeneration, and its regulation

CA Butler, AS Popescu, EJA Kitchener… - Journal of …, 2021 - Wiley Online Library
There is growing evidence that excessive microglial phagocytosis of neurons and synapses
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …

Microglia in the retina: roles in development, maturity, and disease

SM Silverman, WT Wong - Annual review of vision science, 2018 - annualreviews.org
Microglia, the primary resident immune cell type, constitute a key population of glia in the
retina. Recent evidence indicates that microglia play significant functional roles in the retina …

Microglia in CNS development: Shaping the brain for the future

CA Mosser, S Baptista, I Arnoux, E Audinat - Progress in neurobiology, 2017 - Elsevier
Microglial cells are the resident macrophages of the central nervous system (CNS) and are
mainly known for their roles in neuropathologies. However, major recent developments have …

Microglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission

S Marinelli, B Basilico, MC Marrone… - Seminars in cell & …, 2019 - Elsevier
The continuous crosstalk between microglia and neurons is required for microglia
housekeeping functions and contributes to brain homeostasis. Through these exchanges …

Plasticity of microglia

M Augusto‐Oliveira, GP Arrifano, CI Delage… - Biological …, 2022 - Wiley Online Library
Microglial cells are the scions of foetal macrophages which invade the neural tube early
during embryogenesis. The nervous tissue environment instigates the phenotypic …

[HTML][HTML] Microglia gone rogue: impacts on psychiatric disorders across the lifespan

TL Tay, C Béchade, I D'andrea, MK St-Pierre… - Frontiers in molecular …, 2018 - frontiersin.org
Microglia are the predominant immune response cells and professional phagocytes of the
central nervous system (CNS) that have been shown to be important for brain development …

Microglia‐dependent remodeling of neuronal circuits

JR Guedes, PA Ferreira, JM Costa… - Journal of …, 2022 - Wiley Online Library
Microglia are tissue‐resident macrophages responsible for the surveillance, neuronal
support, and immune defense of the brain parenchyma. Recently, the role played by …

[HTML][HTML] Function and dysfunction of microglia during brain development: consequences for synapses and neural circuits

RC Paolicelli, MT Ferretti - Frontiers in Synaptic Neuroscience, 2017 - frontiersin.org
Many diverse factors, ranging from stress to infections, can perturb brain homeostasis and
alter the physiological activity of microglia, the immune cells of the central nervous system …

[HTML][HTML] Microglia, cytokines, and neural activity: unexpected interactions in brain development and function

A Ferro, YSS Auguste, L Cheadle - Frontiers in immunology, 2021 - frontiersin.org
Intercellular signaling molecules such as cytokines and their receptors enable immune cells
to communicate with one another and their surrounding microenvironments. Emerging …

Cerebellar microglia are dynamically unique and survey Purkinje neurons in vivo

RD Stowell, EL Wong, HN Batchelor… - Developmental …, 2018 - Wiley Online Library
Microglia are the innate immune cells of the central nervous system and are also important
participants in normal development and synaptic plasticity. Here, we demonstrate that the …