Nanotechnology-based mRNA vaccines
Abstract mRNA vaccines have emerged as a revolutionary tool to generate rapid and
precise immune responses against infectious diseases and cancers. Compared with …
precise immune responses against infectious diseases and cancers. Compared with …
Drug delivery systems for CRISPR-based genome editors
V Madigan, F Zhang, JE Dahlman - Nature Reviews Drug Discovery, 2023 - nature.com
CRISPR-based drugs can theoretically manipulate any genetic target. In practice, however,
these drugs must enter the desired cell without eliciting an unwanted immune response, so …
these drugs must enter the desired cell without eliciting an unwanted immune response, so …
Induction of bleb structures in lipid nanoparticle formulations of mRNA leads to improved transfection potency
The transfection potency of lipid nanoparticle (LNP) mRNA systems is critically dependent
on the ionizable cationic lipid component. LNP mRNA systems composed of optimized …
on the ionizable cationic lipid component. LNP mRNA systems composed of optimized …
The use of RNA-based treatments in the field of cancer immunotherapy
M Chehelgerdi, M Chehelgerdi - Molecular Cancer, 2023 - Springer
Over the past several decades, mRNA vaccines have evolved from a theoretical concept to a
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
clinical reality. These vaccines offer several advantages over traditional vaccine techniques …
[HTML][HTML] The storage and in-use stability of mRNA vaccines and therapeutics: not a cold case
EO Blenke, E Örnskov, C Schöneich, GA Nilsson… - Journal of …, 2023 - Elsevier
The remarkable impact of mRNA vaccines on mitigating disease and improving public
health has been amply demonstrated during the COVID-19 pandemic. Many new mRNA …
health has been amply demonstrated during the COVID-19 pandemic. Many new mRNA …
Lipid-based nanoparticles for drug/gene delivery: An overview of the production techniques and difficulties encountered in their industrial development
Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery
systems complementing conventional pharmacology has been widely acknowledged …
systems complementing conventional pharmacology has been widely acknowledged …
Amplifying gene expression with RNA-targeted therapeutics
O Khorkova, J Stahl, A Joji, CH Volmar… - Nature Reviews Drug …, 2023 - nature.com
Many diseases are caused by insufficient expression of mutated genes and would benefit
from increased expression of the corresponding protein. However, in drug development, it …
from increased expression of the corresponding protein. However, in drug development, it …
Chemically modified platforms for better RNA therapeutics
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …
landscape, offering unprecedented potential in disease prevention and treatment. However …
Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures
S Meulewaeter, G Nuytten, MHY Cheng… - Journal of Controlled …, 2023 - Elsevier
Messenger RNA (mRNA) lipid nanoparticles (LNPs) have emerged at the forefront during
the COVID-19 vaccination campaign. Despite their tremendous success, mRNA vaccines …
the COVID-19 vaccination campaign. Despite their tremendous success, mRNA vaccines …
Strategies to reduce the risks of mRNA drug and vaccine toxicity
D Bitounis, E Jacquinet, MA Rogers… - Nature Reviews Drug …, 2024 - nature.com
Abstract mRNA formulated with lipid nanoparticles is a transformative technology that has
enabled the rapid development and administration of billions of coronavirus disease 2019 …
enabled the rapid development and administration of billions of coronavirus disease 2019 …