For many years, the dogma has been that insulin resistance precedes the development of
hyperinsulinemia. However, recent data suggest a reverse order and place …

In mammals, the neuroendocrine system, which includes the communication between the
hypothalamus and the pituitary, plays a major role in controlling body growth and cellular …

Background Systematic reviews and meta-analyses of randomized clinical trials (RCTs)
have reported the benefits of ketogenic diets (KD) in various participants such as patients …

Growth hormone (GH) and insulin-like growth factor-1 (IGF-I) are pleiotropic hormones with
important roles in lifespan. They promote growth, anabolic actions, and body maintenance …

Polycystic ovary syndrome (PCOS) is a common endocrinopathy occurring in reproductive-
age women. Hyperandrogenism, polycystic ovaries, chronic anovulation, and metabolic …

Obesity remains a serious relevant public health concern throughout the world despite
related countermeasures being well understood (ie mainly physical activity and an adjusted …

Growth hormone and its mediator insulin‐like growth factor‐1 exert their effect on different
organs and control various physiologic metabolic processes. Adult growth hormone …

Non-pituitary growth hormone (npGH) expression is well established in extrapituitary
tissues, but an understanding of the physiological role of npGH remains rather limited. Pro …

Tackling the mechanisms underlying ageing is desirable to help to extend the duration and
improve the quality of life. Life extension has been achieved in animal models by …

Context Breast cancer is increasing in prevalence in parallel with rising rates of obesity
worldwide. Obesity is recognized as a leading modifiable risk factor for the development of …