Update on poly (ADP-ribose) polymerase inhibitors resistance in ovarian cancer
R Dong, T Ding, Z Li - Frontiers in Pharmacology, 2023 - frontiersin.org
Ovarian cancer is one of the most common reproductive system tumors. The incidence of
ovarian cancer in China is on the rise. Poly (ADP-ribose) polymerase (PARP) inhibitor …
ovarian cancer in China is on the rise. Poly (ADP-ribose) polymerase (PARP) inhibitor …
Inhibition of nicotinamide dinucleotide salvage pathway counters acquired and intrinsic poly (ADP-ribose) polymerase inhibitor resistance in high-grade serous …
SA Sauriol, E Carmona, ML Udaskin, N Radulovich… - Scientific Reports, 2023 - nature.com
Epithelial ovarian cancer is the most lethal gynecological malignancy, owing notably to its
high rate of therapy-resistant recurrence in spite of good initial response to chemotherapy …
high rate of therapy-resistant recurrence in spite of good initial response to chemotherapy …
Overcoming Temozolomide Resistance in Glioblastoma via Enhanced NAD+ Bioavailability and Inhibition of Poly-ADP-Ribose Glycohydrolase
Simple Summary Glioblastoma is the most prevalent and lethal brain tumor type, often
treated with the DNA alkylating agent temozolomide (TMZ). The cytotoxic DNA lesion O6 …
treated with the DNA alkylating agent temozolomide (TMZ). The cytotoxic DNA lesion O6 …
CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancer
Chemoresistance contributes to the majority of deaths in women with ovarian cancer (OC).
Altered DNA repair and metabolic signaling is implicated in mediating therapeutic …
Altered DNA repair and metabolic signaling is implicated in mediating therapeutic …
Replication Associated Base Excision Repair Regulates Replication Stress Induced PARP1/PARP2 Activation and Impacts PARP and PARG Inhibitor Resistance
M Ibrahim - 2022 - search.proquest.com
Endogenous and exogenous genotoxins pose a significant challenge to the DNA replication
machinery, contributing to replication stress, a phenotype common in pre-cancerous and …
machinery, contributing to replication stress, a phenotype common in pre-cancerous and …