Tumor mutational burden (TMB), defined as the number of somatic mutations per megabase
of interrogated genomic sequence, varies across malignancies. Panel sequencing–based …

Background: Head and neck squamous cell carcinoma (HNSCC) exists within a
microenvironment rich in immune cells. Macrophages are particularly abundant in and …

Background Survival analysis is a cornerstone of medical research, enabling the
assessment of clinical outcomes for disease progression and treatment efficiency. Despite …

Understanding the mechanisms underlying evasive resistance in cancer is an unmet
medical need to improve the efficacy of current therapies. In this study, a combination of …

Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the
molecular and genetic bases of such sex differences are ill-defined and presumptively …

Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue …

Background & Aims In recent years, circular RNAs (circRNAs) have been shown to have
critical regulatory roles in cancer biology. However, the contributions of circRNAs to …

Background Previous studies have suggested that elevated neutrophil-to-lymphocyte ratio
(NLR) is prognostic for worse outcomes in patients with a variety of solid cancers, including …

Tumour-infiltrating immune cells are a source of important prognostic information for patients
with resectable colon cancer. We developed a novel immune model based on systematic …

Validation of multi-gene biomarkers for clinical outcomes is one of the most important issues
for cancer prognosis. An important source of information for virtual validation is the high …