Simple Summary Ca2+ dyshomeostasis is implicated in several key pathophysiological
processes attributed to cancer metastasis biology. Here, we decipher the role of intracellular …

Anthracyclines are one of the most widely used and effective chemotherapies in oncology,
but their most important side effect is the cumulative, dose-related cardiotoxicity leading to …

Macrophages polarization in bone immune microenvironment is crucial in bone
regeneration. In this work, mineralized collagen (MC) coatings with photo-thermal effect …

Environmental temperature and cellular mechanical force are the inherent factors that
participate in various biological processes and regulate cancer progress, which have been …

Cannabinoids are a major class of compounds produced by the plant Cannabis sativa.
Previous work has demonstrated that the main cannabinoids cannabidiol (CBD) and …

The search for new therapeutical targets for cutaneous melanoma and other cancers is an
ongoing task. We expanded this knowledge by evaluating whether opsins, light-and thermo …

Crosstalk between ion channels and small GTPases is critical during homeostasis and
disease, but little is known about the structural underpinnings of these interactions. TRPV4 is …

Transient receptor potential melastatin 4 (TRPM4) is widely expressed in various organs
and associated with cardiovascular and immune diseases. Lately, the interest in studies on …

Metastatic cancer is one of the major causes of cancer-related mortalities. Metastasis is a
complex, multi-process phenomenon, and a hallmark of cancer. Calcium (Ca2+) is a …

Background Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent renal
malignant tumors, which survival rate and quality of life of ccRCC patients are not …