Imaging the substantia nigra in Parkinson disease and other Parkinsonian syndromes

YJ Bae, JM Kim, CH Sohn, JH Choi, BS Choi, YS Song… - Radiology, 2021 - pubs.rsna.org
Parkinson disease is characterized by dopaminergic cell loss in the substantia nigra of the
midbrain. There are various imaging markers for Parkinson disease. Recent advances in …

Imaging the limbic system in Parkinson's disease—a review of limbic pathology and clinical symptoms

M Banwinkler, H Theis, S Prange, T van Eimeren - Brain sciences, 2022 - mdpi.com
The limbic system describes a complex of brain structures central for memory, learning, as
well as goal directed and emotional behavior. In addition to pathological studies, recent …

Kidney damage causally affects the brain cortical structure: a Mendelian randomization study

X Chen, J Kong, J Pan, K Huang, W Zhou, X Diao… - …, 2021 - thelancet.com
Background Alterations in the brain cortical structures of patients with chronic kidney
disease (CKD) have been reported; however, the cause has not been determined yet …

The default mode network and cognition in Parkinson's disease: A multimodal resting‐state network approach

MC Ruppert, A Greuel, J Freigang… - Human brain …, 2021 - Wiley Online Library
Involvement of the default mode network (DMN) in cognitive symptoms of Parkinson's
disease (PD) has been reported by resting‐state functional MRI (rsfMRI) studies. However …

Morphological basis of Parkinson disease-associated cognitive impairment: an update

KA Jellinger - Journal of Neural Transmission, 2022 - Springer
Cognitive impairment is one of the most salient non-motor symptoms of Parkinson disease
(PD) that poses a significant burden on the patients and carers as well as being a risk factor …

TGR5 agonist INT-777 alleviates inflammatory neurodegeneration in Parkinson's disease mouse model by modulating mitochondrial dynamics in microglia

R Huang, Y Gao, J Chen, Q Duan, P He, J Zhang… - Neuroscience, 2022 - Elsevier
Parkinson's disease (PD) is one of the most common chronic progressive
neurodegenerative diseases that affects both motor and non-motor functions. Bile acids …

Pathobiology of cognitive impairment in Parkinson disease: challenges and outlooks

KA Jellinger - International Journal of Molecular Sciences, 2023 - mdpi.com
Cognitive impairment (CI) is a characteristic non-motor feature of Parkinson disease (PD)
that poses a severe burden on the patients and caregivers, yet relatively little is known about …

Longitudinal clinical, cognitive, and neuroanatomical changes over 5 years in GBA-positive Parkinson's disease patients

M Leocadi, E Canu, G Donzuso, T Stojkovic… - Journal of …, 2022 - Springer
Objective To study the longitudinal disease course of Parkinson's disease (PD) patients with
glucocerebrosidase (GBA) mutation (GBA-positive) compared to PD non-carriers (GBA …

[HTML][HTML] Regional changes of brain structure during progression of idiopathic Parkinson's disease–A longitudinal study using deformation based morphometry

P Pieperhoff, M Südmeyer, L Dinkelbach, CJ Hartmann… - Cortex, 2022 - Elsevier
Idiopathic Parkinson's disease (PD) is a neurodegenerative disorder with a broad spectrum
of motor and non-motor symptoms. The neuropathological characteristics of idiopathic PD …

A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson's disease

S Huang, Z Chen, B Fan, Y Chen, L Zhou… - Journal of …, 2021 - Elsevier
Nod-like receptor pyrin containing (NLRP) 3 inflammasome-mediated neuroinflammation is
involved in the pathology of Parkinson's disease (PD), but the roles of other inflammasomes …