The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease among
adults. With diagnosis reached relatively late into the disease process, extensive motor cell …

The routine clinical integration of individualized objective markers of disease activity in those
diagnosed with the neurodegenerative disorder amyotrophic lateral sclerosis is a key …

Abstract Chitinase‐3‐like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its
ability to regulate multiple biological processes, such as the inflammatory response and …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
loss of upper and lower motor neurons, resulting in progressive weakness of all voluntary …

Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative disease,
and only modest disease-modifying strategies have been established to date. Numerous …

Several reports have pointed out that Chitinases are expressed and secreted by various cell
types of central nervous system (CNS), including activated microglia and astrocytes. These …

Behçet's syndrome (BS) is a systemic vasculitis with several clinical manifestations.
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …

Background Premorbid body mass index, physical activity, diabetes and cardiovascular
disease have been associated with an altered risk of developing amyotrophic lateral …

Although the past two decades have produced exciting discoveries in the genetics and
pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy …