Calcium handling defects and cardiac arrhythmia syndromes
Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling.
Intracellular Ca2+ concentration increases during systole and falls in diastole thereby …
Intracellular Ca2+ concentration increases during systole and falls in diastole thereby …
Murine electrophysiological models of cardiac arrhythmogenesis
CLH Huang - Physiological reviews, 2017 - journals.physiology.org
Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …
processes underlying excitable activity and their tissue propagation as coherent wavefronts …
Insights into the pathogenesis of catecholaminergic polymorphic ventricular tachycardia from engineered human heart tissue
Background: Modeling of human arrhythmias with induced pluripotent stem cell–derived
cardiomyocytes has focused on single-cell phenotypes. However, arrhythmias are the …
cardiomyocytes has focused on single-cell phenotypes. However, arrhythmias are the …
Machine learning of electrophysiological signals for the prediction of ventricular arrhythmias: systematic review and examination of heterogeneity between studies
MZH Kolk, B Deb, S Ruipérez-Campillo, NK Bhatia… - …, 2023 - thelancet.com
Background Ventricular arrhythmia (VA) precipitating sudden cardiac arrest (SCD) is among
the most frequent causes of death and pose a high burden on public health systems …
the most frequent causes of death and pose a high burden on public health systems …
[HTML][HTML] High-resolution noncontact charge-density mapping of endocardial activation
BACKGROUND. Spatial resolution in cardiac activation maps based on voltage
measurement is limited by far-field interference. Precise characterization of electrical …
measurement is limited by far-field interference. Precise characterization of electrical …
Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics
N Chiamvimonvat, Y Chen‐Izu… - The Journal of …, 2017 - Wiley Online Library
This is the second of the two White Papers from the fourth UC Davis Cardiovascular
Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling …
Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling …
Injectable hydrogel electrodes as conduction highways to restore native pacing
There is an urgent clinical need for a treatment regimen that addresses the underlying
pathophysiology of ventricular arrhythmias, the leading cause of sudden cardiac death. The …
pathophysiology of ventricular arrhythmias, the leading cause of sudden cardiac death. The …
Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications
Animal experimentation is key in the evaluation of cardiac efficacy and safety of novel
therapeutic compounds. However, interspecies differences in the mechanisms regulating …
therapeutic compounds. However, interspecies differences in the mechanisms regulating …
R-from-T as a common mechanism of arrhythmia initiation in long QT syndromes
MB Liu, N Vandersickel, AV Panfilov… - Circulation: Arrhythmia …, 2019 - Am Heart Assoc
Background: Long QT syndromes (LQTS) arise from many genetic and nongenetic causes
with certain characteristic ECG features preceding polymorphic ventricular tachyarrhythmias …
with certain characteristic ECG features preceding polymorphic ventricular tachyarrhythmias …
Cardioprotective actions of relaxin
Relaxin is a hormone of pregnancy first discovered for its ability to induce ligament
relaxation in nonpregnant guinea pig and is important for softening of the birth canal during …
relaxation in nonpregnant guinea pig and is important for softening of the birth canal during …