Aptamers targeting membrane proteins for sensor and diagnostic applications

N Kara, N Ayoub, H Ilgu, D Fotiadis, M Ilgu - Molecules, 2023 - mdpi.com
Many biological processes (physiological or pathological) are relevant to membrane
proteins (MPs), which account for almost 30% of the total of human proteins. As such, MPs …

X-linked hydrocephalus genes: Their proximity to telomeres and high A+ T content compared to Parkinson's disease

M Hart, J Conrad, E Barrett, K Legg, G Ivey… - Experimental …, 2023 - Elsevier
Proximity to telomeres (i) and high adenine and thymine (A+ T) content (ii) are two factors
associated with high mutation rates in human chromosomes. We have previously shown …

TRPV4 mRNA is elevated in the caudate nucleus with NPH but not in Alzheimer's disease

H White, R Webb, I McKnight, K Legg, C Lee… - Frontiers in …, 2022 - frontiersin.org
Symptoms of normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD) are
somewhat similar, and it is common to misdiagnose these two conditions. Although there are …

Reduced GLP-1R availability in the caudate nucleus with Alzheimer's disease

E Barrett, G Ivey, A Cunningham, G Coffman… - Frontiers in Aging …, 2024 - frontiersin.org
The glucagon-like peptide-1 receptor (GLP-1R) agonists reduce glycated hemoglobin in
patients with type 2 diabetes. Mounting evidence indicates that the potential of GLP-1R …

Activation mechanism of RhoA caused by constitutively activating mutations G14V and Q63L

S Chen, Z Zhang, Y Zhang, T Choi, Y Zhao - International Journal of …, 2022 - mdpi.com
RhoA, a member of Rho GTPases, regulates myriad cellular processes. Abnormal
expression of RhoA has been implicated in various diseases, including cancers …

[HTML][HTML] Morin hydrate promotes nephrin expression through modulation of Notch1-Snail signalling pathway in diabetic rats

AO Lawal, IM Folorunso, O Adebisi… - Aspects of Molecular …, 2023 - Elsevier
Reduction in nephrin expression is usually observed in patients with diabetic nephropathy,
and there is evidence that Notch1/Snail signalling pathway is essential for the expression of …

Mutability of druggable kinases and pro-inflammatory cytokines by their proximity to telomeres and A+ T content

I McKnight, R Raines, H White, N Nosoudi, C Lee… - Plos one, 2023 - journals.plos.org
Mutations of protein kinases and cytokines are common and can cause cancer and other
diseases. However, our understanding of the mutability in these genes remains rudimentary …

[PDF][PDF] Aspects of Molecular Medicine

AO Lawal, IM Folorunso, O Adebisi, OF Koledoye… - researchgate.net
Reduction in nephrin expression is usually observed in patients with diabetic nephropathy,
and there is evidence that Notch1/Snail signalling pathway is essential for the expression of …