Perivascular spaces in the brain: anatomy, physiology and pathology

JM Wardlaw, H Benveniste, M Nedergaard… - Nature Reviews …, 2020 - nature.com
Perivascular spaces include a variety of passageways around arterioles, capillaries and
venules in the brain, along which a range of substances can move. Although perivascular …

Understanding the role of the perivascular space in cerebral small vessel disease

R Brown, H Benveniste, SE Black… - Cardiovascular …, 2018 - academic.oup.com
Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …

Perivascular spaces, glymphatic dysfunction, and small vessel disease

H Mestre, S Kostrikov, RI Mehta… - Clinical …, 2017 - portlandpress.com
Cerebral small vessel diseases (SVDs) range broadly in etiology but share remarkably
overlapping pathology. Features of SVD including enlarged perivascular spaces (EPVS) …

Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex

V Perosa, J Oltmer, LP Munting, WM Freeze… - Acta …, 2022 - Springer
Perivascular spaces (PVS) are compartments surrounding cerebral blood vessels that
become visible on MRI when enlarged. Enlarged PVS (EPVS) are commonly seen in …

[HTML][HTML] Cerebral perivascular spaces visible on magnetic resonance imaging: development of a qualitative rating scale and its observer reliability

GM Potter, FM Chappell, Z Morris… - Cerebrovascular …, 2015 - karger.com
Background: Perivascular spaces (PVS) are an important component of cerebral small
vessel disease (SVD), several inflammatory disorders, hypertension and blood-brain barrier …

Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: a systematic review and meta-analysis

F Francis, L Ballerini… - International Journal of …, 2019 - journals.sagepub.com
Background Perivascular spaces, visible on brain magnetic resonance imaging, are thought
to be associated with small vessel disease, neuroinflammation, and to be important for …

Consensus statement for diagnosis of subcortical small vessel disease

GA Rosenberg, A Wallin, JM Wardlaw… - Journal of Cerebral …, 2016 - journals.sagepub.com
Vascular cognitive impairment (VCI) is the diagnostic term used to describe a
heterogeneous group of sporadic and hereditary diseases of the large and small blood …

Global and regional changes in perivascular space in idiopathic and familial Parkinson's disease

EK Donahue, A Murdos, MW Jakowec… - Movement …, 2021 - Wiley Online Library
Background The glymphatic system, including the perivascular space (PVS), plays a critical
role in brain homeostasis. Although mounting evidence from Alzheimer's disease has …

White matter changes in dementia: role of impaired drainage of interstitial fluid

RO Weller, CA Hawkes, RN Kalaria… - Brain …, 2015 - Wiley Online Library
White matter abnormalities on magnetic resonance imaging (MRI) are associated with
dementia and include white matter hyperintensities (WMH; also termed leukoaraiosis) and …

Topography and associations of perivascular spaces in healthy adults: the Kashima scan study

Y Yakushiji, A Charidimou, M Hara, T Noguchi… - Neurology, 2014 - AAN Enterprises
Objective: We investigated whether the topography of MRI-visible perivascular spaces (PVS)
is associated with markers of specific underlying small vessel disease, including cerebral …