HPMA copolymers: origins, early developments, present, and future
J Kopeček, P Kopečková - Advanced drug delivery reviews, 2010 - Elsevier
The overview covers the discovery of N-(2-hydroxypropyl) methacrylamide (HPMA)
copolymers, initial studies on their synthesis, evaluation of biological properties, and …
copolymers, initial studies on their synthesis, evaluation of biological properties, and …
Immune system targeting by biodegradable nanoparticles for cancer vaccines
The concept of therapeutic cancer vaccines is based on the activation of the immune system
against tumor cells after the presentation of tumor antigens. Nanoparticles (NPs) have …
against tumor cells after the presentation of tumor antigens. Nanoparticles (NPs) have …
Doxorubicin-loaded, charge reversible, folate modified HPMA copolymer conjugates for active cancer cell targeting
L Li, Q Yang, Z Zhou, J Zhong, Y Huang - Biomaterials, 2014 - Elsevier
Although folate exhibits many advantages over other targeting ligands, it has one major
defect: poor water solubility. Once it was conjugated to hydrophilic drug carrier such as N-(2 …
defect: poor water solubility. Once it was conjugated to hydrophilic drug carrier such as N-(2 …
MDR in cancer: Addressing the underlying cellular alterations with the use of nanocarriers
Multidrug resistance (MDR) is associated with a wide range of pathological changes at
different cellular and intracellular levels. Nanoparticles (NPs) have been extensively …
different cellular and intracellular levels. Nanoparticles (NPs) have been extensively …
Poly (2-methyl-2-oxazoline) conjugates with doxorubicin: From synthesis of high drug loading water-soluble constructs to in vitro anti-cancer properties
O Sedlacek, A Van Driessche, A Uvyn… - Journal of controlled …, 2020 - Elsevier
Abstract Poly (2-oxazoline) s represent an emerging class of polymers with increasing
potential in biomedical sciences. To date, most of the work on poly (2-oxazoline)-drug …
potential in biomedical sciences. To date, most of the work on poly (2-oxazoline)-drug …
Nanoparticle-mediated drug delivery for treating melanoma
Melanoma originated from melanocytes is the most aggressive type of skin cancer with
limited treatment options. New targeted therapeutic options with the discovery of BRAF and …
limited treatment options. New targeted therapeutic options with the discovery of BRAF and …
Impact of polymer-TLR-7/8 agonist (adjuvant) morphology on the potency and mechanism of CD8 T cell induction
Small molecule Toll-like receptor-7 and-8 agonists (TLR-7/8a) can be used as vaccine
adjuvants to induce CD8 T cell immunity but require formulations that prevent systemic …
adjuvants to induce CD8 T cell immunity but require formulations that prevent systemic …
Design of smart HPMA copolymer-based nanomedicines
The state-of-the art in water-soluble macromolecular therapeutics has been reviewed. First
the design principles for polymer-drug conjugates are discussed followed by two recent …
the design principles for polymer-drug conjugates are discussed followed by two recent …
[HTML][HTML] Development of non-viral, trophoblast-specific gene delivery for placental therapy
N Abd Ellah, L Taylor, W Troja, K Owens, N Ayres… - PloS one, 2015 - journals.plos.org
Low birth weight is associated with both short term problems and the fetal programming of
adult onset diseases, including an increased risk of obesity, diabetes and cardiovascular …
adult onset diseases, including an increased risk of obesity, diabetes and cardiovascular …