Investigation of cerebrospinal fluid (CSF) in the diagnostic work-up in suspected multiple
sclerosis (MS) patients has regained attention in the latest version of the diagnostic criteria …

Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple
sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of …

Objective: To determine the frequency and nature of leptomeningeal contrast enhancement
in multiple sclerosis (MS) via in vivo 3-tesla postcontrast T2-weighted, fluid-attenuated …

The advent of highly effective disease modifying therapy has transformed the landscape of
multiple sclerosis (MS) care over the last two decades. However, there remains a critical …

Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or
diagnostic autoantibody remains elusive. In this study, the Department of Defense Serum …

Objective The management of complex patients with neuroimmunological diseases is
hindered by an inability to reliably measure intrathecal inflammation. Currently implemented …

Objective: To validate kappa free light chain (KFLC) and lambda free light chain (LFLC)
indices as a diagnostic biomarker in multiple sclerosis (MS). Methods: We performed a …

There is a strong unmet clinical need for objective body fluid biomarkers to assist early
diagnosis and estimate long-term prognosis, monitor treatment response and predict …

Oligoclonal immunoglobulin G (IgG) bands (OCBs) are a useful diagnostic tool to detect a
central humoral response. In particular, cerebrospinal fluid (CSF)-restricted OCBs represent …

There is no consensus regarding the classification of optic neuritis, and precise diagnostic
criteria are not available. This reality means that the diagnosis of disorders that have optic …