[HTML][HTML] The evolving role of investigative toxicology in the pharmaceutical industry

F Pognan, M Beilmann, H Boonen, A Czich… - Nature reviews drug …, 2023 - nature.com
For decades, preclinical toxicology was essentially a descriptive discipline in which
treatment-related effects were carefully reported and used as a basis to calculate safety …

Deciphering the relationship between SARS-CoV-2 and cancer

M Costanzo, MAR De Giglio, GN Roviello - International Journal of …, 2023 - mdpi.com
Some viruses are known to be associated with the onset of specific cancers. These
microorganisms, oncogenic viruses or oncoviruses, can convert normal cells into cancer …

8-Hydroxy-2-Deoxyguanosine and 8-Iso-prostaglandin F2α: putative biomarkers to assess oxidative stress damage following Robot-assisted radical prostatectomy …

A Di Minno, A Aveta, M Gelzo, L Tripodi… - Journal of Clinical …, 2022 - mdpi.com
Objective: Prostate cancer (PCa) is the most common type of cancer. Biomarkers help
researchers to understand the mechanisms of disease and refine diagnostic panels. We …

Decoding metabolic reprogramming in plants under pathogen attacks, a comprehensive review of emerging metabolomics technologies to maximize their applications

A Serag, MA Salem, S Gong, JL Wu, MA Farag - Metabolites, 2023 - mdpi.com
In their environment, plants interact with a multitude of living organisms and have to cope
with a large variety of aggressions of biotic or abiotic origin. What has been known for …

Fingerprinting and profiling in metabolomics of biosamples

V Ghini, G Meoni, A Vignoli, F Di Cesare… - Progress in Nuclear …, 2023 - Elsevier
This review focuses on metabolomics from an NMR point of view. It attempts to cover the
broad scope of metabolomics and describes the NMR experiments that are most suitable for …

Metabolomics as an emerging approach for deciphering the biological impact and toxicity of food contaminants: The case of mycotoxins

P Mandal, O Lanaridi, B Warth… - Critical Reviews in Food …, 2023 - Taylor & Francis
Exposure to mycotoxins through the dietary route occurs on a daily basis while their
deleterious effects are exhibited in the form of ailments, such as inflammation, cancer, and …

Current state and future perspectives on personalized metabolomics

OP Trifonova, DL Maslov, EE Balashova, PG Lokhov - Metabolites, 2023 - mdpi.com
Metabolomics is one of the most promising 'omics' sciences for the implementation in
medicine by developing new diagnostic tests and optimizing drug therapy. Since in …

A comparative metabolomics study of polyphenols in highland barley (Hordeum vulgare L.) grains with different colors

Y Yang, B Fan, Y Mu, Y Li, L Tong, L Wang, L Liu… - Food Research …, 2023 - Elsevier
Highland barley (HB) grains are gaining increasing popularity owing to their high nutritional
merits. However, only limited information is available on the metabolic profiles of HB grains …

[HTML][HTML] Edaravone counteracts redox and metabolic disruptions in an emerging zebrafish model of sporadic ALS

NAS Oliveira, BR Pinho, J Pinto, PG de Pinho… - Free Radical Biology …, 2024 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which the death of
motor neurons leads to loss of muscle function. Additionally, cognitive and circadian …

[HTML][HTML] 3D superstructure based metabolite profiling for glaucoma diagnosis

M Jang, J Shin, YH Kim, TY Jeong, S Jo, SJ Kim… - Biosensors and …, 2024 - Elsevier
Metabolome analysis has gained widespread application in disease diagnosis owing to its
ability to provide comprehensive information, including disease phenotypes. In this study …