Bone morphogenetic protein signaling: the pathway and its regulation

T Akiyama, LA Raftery, KA Wharton - Genetics, 2024 - academic.oup.com
In the mid-1960s, bone morphogenetic proteins (BMPs) were first identified in the extracts of
bone to have the remarkable ability to induce heterotopic bone. When the Drosophila gene …

The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth

S Yang, X Wu, EI Daoutidou, Y Zhang, MJ Shimell… - Elife, 2022 - elifesciences.org
Abstract Hedgehog (Hh) and Bone Morphogenetic Proteins (BMPs) pattern the developing
Drosophila wing by functioning as short-and long-range morphogens, respectively. Here, we …

Differential heparan sulfate dependency of the Drosophila glypicans

E Nakato, K Kamimura, C Knudsen, S Masutani… - Journal of Biological …, 2024 - ASBMB
Heparan sulfate proteoglycans (HSPGs) are composed of a core protein and
glycosaminoglycan (GAG) chains and serve as coreceptors for many growth factors and …

Nematode Extracellular Protein Interactome Expands Connections between Signaling Pathways

WI Nawrocka, S Cheng, B Hao, MC Rosen, E Cortés… - bioRxiv, 2024 - biorxiv.org
Multicellularity was accompanied by the emergence of new classes of cell surface and
secreted proteins. The nematode C. elegans is a favorable model to study cell surface …

Identifying Fibroblast Growth Factor Receptor 3 as a Mediator of Periosteal Osteochondral Differentiation through the Construction of microRNA-Based Interaction …

LM Wells, HC Roberts, FP Luyten, SJ Roberts - Biology, 2023 - mdpi.com
Simple Summary The cartilage-to-bone transition is an essential process in healthy bone
development and repair. Our previous work has shown that when the cells found within the …