Metabolites once considered solely in catabolism or anabolism turn out to have key
regulatory functions. Among these, the citric acid cycle intermediate succinate stands out …

Pharmacological conditioning aims to protect the heart from myocardial ischemia-
reperfusion injury (IRI). Despite extensive research in this area, today, a significant gap …

Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and
then restored, and underlies many disorders, notably heart attack and stroke. While …

Succinate is a signaling metabolite sensed extracellularly by succinate receptor 1
(SUNCR1). The accumulation of succinate in macrophages is known to activate a pro …

The citric acid cycle (CAC) metabolite fumarate has been proposed to be cardioprotective;
however, its mechanisms of action remain to be determined. To augment cardiac fumarate …

The term “energy metabolism” used to be synonymous with the term “biochemistry of the
heart.” It refers to the large number of interconnected, enzyme-catalyzed reactions …

Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular
matrix in the lung with fibroblast-to-myofibroblast transition, leading to chronically …

We critically assess the proposal that succinate-fuelled reverse electron flow (REF) drives
mitochondrial matrix superoxide production from Complex I early in reperfusion, thus acting …

The article is focused on the role of the cell bioenergetic apparatus, mitochondria, involved
in development of immediate and delayed molecular mechanisms for adaptation to hypoxic …

Since it was discovered, the citric acid cycle has been known to be central to cell metabolism
and energy homeostasis. Mainly found in the mitochondrial matrix, some of the …