[HTML][HTML] Impaired AT2 to AT1 cell transition in PM2. 5-induced mouse model of chronic obstructive pulmonary disease

H Yu, Y Lin, Y Zhong, X Guo, Y Lin, S Yang, J Liu… - Respiratory …, 2022 - Springer
Abstract Background Particular matter 2.5 (PM2. 5) is one of the most important air pollutant,
and it is positively associated with the development of chronic obstructive pulmonary …

Interfering with SARS-CoV-2: are interferons friends or foes in COVID-19?

I Zanoni - Current Opinion in Virology, 2021 - Elsevier
Type I and type III interferons are among the most potent anti-viral cytokines produced by the
immune system. The recent outbreak of SARS-CoV-2, which causes COVID-19 …

Increased sensitivity of SARS-CoV-2 to type III interferon in human intestinal epithelial cells

C Metz-Zumaran, C Kee, P Doldan, C Guo… - Journal of …, 2022 - Am Soc Microbiol
The coronavirus SARS-CoV-2 caused the COVID-19 global pandemic leading to 5.3 million
deaths worldwide as of December 2021. The human intestine was found to be a major viral …

[HTML][HTML] In vitro lung models and their application to study SARS-CoV-2 pathogenesis and disease

N Heinen, M Kloehn, E Steinmann, S Pfaender - Viruses, 2021 - mdpi.com
SARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has
put scientist and pharmaceutical companies worldwide on the spot to develop novel …

[HTML][HTML] Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19

M Kiener, N Roldan, C Machahua, A Sengupta… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic has caused considerable socio-
economic burden, which fueled the development of treatment strategies and vaccines at an …

[HTML][HTML] Improved SARS-CoV-2 sequencing surveillance allows the identification of new variants and signatures in infected patients

A Grimaldi, F Panariello, P Annunziata, T Giuliano… - Genome Medicine, 2022 - Springer
Background Genomic surveillance of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is the only approach to rapidly monitor and tackle emerging variants of …

Stem cells in pulmonary alveolar regeneration

H Wu, N Tang - Development, 2021 - journals.biologists.com
The lungs are constantly exposed to the external environment and are therefore vulnerable
to insults that can cause infection and injury. Maintaining the integrity and barrier function of …

[HTML][HTML] Tropism of SARS-CoV-2 for developing human cortical astrocytes

MG Andrews, T Mukhtar, UC Eze, CR Simoneau… - BioRxiv, 2021 - ncbi.nlm.nih.gov
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) readily infects a variety
of cell types impacting the function of vital organ systems, with particularly severe impact on …

[HTML][HTML] Studying SARS-CoV-2 infectivity and therapeutic responses with complex organoids

KG Chen, K Park, JR Spence - Nature cell biology, 2021 - nature.com
Clinical management of patients with severe complications of COVID-19 has been hindered
by a lack of effective drugs and a failure to capture the extensive heterogeneity of the …

[HTML][HTML] SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK

Y Yang, Y Wu, X Meng, Z Wang, M Younis… - Cell Death & …, 2022 - nature.com
Deaths caused by coronavirus disease 2019 (COVID-19) are largely due to the lungs
edema resulting from the disruption of the lung alveolo-capillary barrier, induced by SARS …