The global health emergency for SARS-CoV-2 (COVID-19) created an urgent need to
develop new treatments and therapeutic drugs. In this study, we tested, for the first time on …

Single-cell RNA sequencing (scRNA-seq) of BAL cells has provided insights into
coronavirus disease (COVID-19). However, reports have been limited by small patient …

Over the last two decades the world has witnessed the global spread of two genetically
related highly pathogenic coronaviruses, severe acute respiratory syndrome coronavirus …

The global burden of respiratory diseases is very high and still on the rise, prompting the
need for accurate models for basic and translational research. Several model systems are …

A hallmark of idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases is
dysregulated repair of the alveolar epithelium. The Hippo pathway effector transcription …

Lung alveolar structure and function are maintained by subsets of alveolar type II stem cells
(AT2s), but there is a need for characterization of these subsets and their associated niches …

Mechanisms of epithelial renewal in the alveolar compartment remain incompletely
understood. To this end, we aimed to characterize alveolar progenitors. Single-cell RNA …

The substantial socioeconomic burden of lung diseases, recently highlighted by the
disastrous impact of the coronavirus disease 2019 (COVID‐19) pandemic, accentuates the …

Alveolar epithelial cell fate decisions drive lung development and regeneration. Using
transcriptomic and epigenetic profiling coupled with genetic mouse and organoid models …

The risk of developing severe COVID‐19 rises dramatically with age. Schoolchildren are
significantly less likely than older people to die from SARS‐CoV‐2 infection, but the …