Cell-penetrating peptides: Promising therapeutics and drug-delivery systems for neurodegenerative diseases

M Pirhaghi, F Mamashli… - Molecular …, 2024 - ACS Publications
Currently, one of the most significant and rapidly growing unmet medical challenges is the
treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's …

[HTML][HTML] Recent Uses of Lipid Nanoparticles, Cell-Penetrating and Bioactive Peptides for the Development of Brain-Targeted Nanomedicines against …

Y Wu, A Angelova - Nanomaterials, 2023 - mdpi.com
The lack of effective treatments for neurodegenerative diseases (NDs) is an important
current concern. Lipid nanoparticles can deliver innovative combinations of active molecules …

Metallic nanocarriers for therapeutic peptides: Emerging solutions addressing the delivery challenges in brain ailments

SS Rathnam, T Deepak, BN Sahoo, T Meena… - … of Pharmacology and …, 2024 - ASPET
Peptides and proteins have recently emerged as efficient therapeutic alternatives to
conventional therapies. Although they emerged a few decades back, extensive exploration …

Lipid-Based Nanoparticle Functionalization with Coiled-Coil Peptides for In Vitro and In Vivo Drug Delivery

D Aschmann, RA Knol, A Kros - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus For the delivery of drugs, different nanosized drug carriers (eg, liposomes, lipid
nanoparticles, and micelles) have been developed in order to treat diseases that afflict …

Role of NLRP3 Inflammasome in Stroke Pathobiology: Current Therapeutic Avenues and Future Perspective

K Panbhare, R Pandey, C Chauhan… - ACS Chemical …, 2023 - ACS Publications
Neuroinflammation is a key pathophysiological feature of stroke-associated brain injury. A
local innate immune response triggers neuroinflammation following a stroke via activating …

Brain Targeting Nanomedicines: Pitfalls and Promise

A Kakinen, Y Jiang, TP Davis, T Teesalu… - International Journal of …, 2024 - Taylor & Francis
Brain diseases are the most devastating problem among the world's increasingly aging
population, and the number of patients with neurological diseases is expected to increase in …

[HTML][HTML] Non-Invasive Device-Mediated Drug Delivery to the Brain across the Blood–Brain Barrier

T Tashima, N Tournier - Pharmaceutics, 2024 - mdpi.com
We will be serving as the Guest Editor for this very interesting Special Issue on “Non-
Invasive Device-Mediated Drug Delivery to the Brain Across the Blood–Brain Barrier”. It is …

Peptide‐conjugated Nanoparticle Platforms for Targeted Delivery, Imaging, and Biosensing Applications

BD Ilieş, I Yildiz, M Abbas - ChemBioChem, 2024 - Wiley Online Library
Peptides have become an indispensable tool in engineering of multifunctional nanostructure
platforms for biomedical applications such as targeted drug and gene delivery, imaging and …

Mucosal absorption of antibody drugs enhanced by cell-penetrating peptides anchored to a platform of polysaccharides

T Tomono, H Yagi, R Igi, A Tabaru, K Fujimoto… - International Journal of …, 2023 - Elsevier
Our previous studies demonstrated that L-octaarginine grafted onto hyaluronic acid via a
tetraglycine spacer significantly enhanced intranasal absorption of protein drugs with a …

[HTML][HTML] Molecular determinants for brain targeting by peptides: a meta-analysis approach with experimental validation

M Cavaco, P Fraga, J Valle, RDM Silva, L Gano… - Fluids and Barriers of …, 2024 - Springer
Blood–brain barrier (BBB) peptide-shuttles (BBBpS) are able to translocate the BBB and
reach the brain. Despite the importance of brain targeting in pharmacology, BBBpS are …