[HTML][HTML] Molecular basis and targeted therapy in thyroid cancer: Progress and opportunities

L Zhang, Q Feng, J Wang, Z Tan, Q Li, M Ge - Biochimica et Biophysica …, 2023 - Elsevier
Thyroid cancer (TC) is the most prevalent endocrine malignant tumor. Surgery,
chemotherapy, radiotherapy, and radioactive iodine (RAI) therapy are the standard TC …

Novel inhibitor-based therapies for thyroid cancer—An update

M Ratajczak, D Gaweł, M Godlewska - International journal of molecular …, 2021 - mdpi.com
Thyroid cancers (TCs) are the most common tumors of the endocrine system and a constant
rise in the number of TC cases has been observed for the past few decades. TCs are one of …

[HTML][HTML] Molecular classification of follicular thyroid carcinoma based on TERT promoter mutations

H Park, HC Shin, H Yang, J Heo, CS Ki, HS Kim… - Modern Pathology, 2022 - Elsevier
Follicular thyroid carcinoma (FTC) has different clinicopathological characteristics than
papillary thyroid carcinoma. However, there are no independent systems to predict cancer …

Efficacy and response biomarkers of apatinib in the treatment of malignancies in China: a review

Z Tian, X Niu, W Yao - Frontiers in Oncology, 2021 - frontiersin.org
Apatinib is a multitarget tyrosine kinase inhibitor marketed in China for the treatment of
advanced gastric cancer (GC) and hepatocellular carcinoma (HCC). It has also been used …

Apatinib weakens proliferation, migration, invasion, and angiogenesis of thyroid cancer cells through downregulating pyruvate kinase M2

X Yang, W Li, X Han, J Wang, J Dai, X Ye, M Meng - Scientific Reports, 2024 - nature.com
Thyroid cancer (TC) is the most frequent malignancy of the endocrine system. Apatinib, as
an anti-angiogenic agent, has been applied in the therapy of several cancers. However, the …

[HTML][HTML] New approaches for patients with advanced radioiodine-refractory thyroid cancer

F Pitoia, F Jerkovich, P Trimboli… - World Journal of Clinical …, 2022 - ncbi.nlm.nih.gov
The cumulative evidence over the past decades has shown that the incidence of
differentiated thyroid carcinoma (DTC) has exponentially increased. Approximately 10% of …

Target therapy in thyroid cancer: current challenge in clinical use of tyrosine kinase inhibitors and management of side effects

I Puliafito, F Esposito, A Prestifilippo… - Frontiers in …, 2022 - frontiersin.org
Thyroid cancer (TC) is the most common endocrine malignancy. TC is classified as
differentiated TC (DTC), which includes papillary and follicular subtypes and Hürthle cell …

Intermittent versus continuous administration of pazopanib in progressive radioiodine refractory thyroid carcinoma: Final results of the randomised, multicenter, open …

C de la Fouchardière, Y Godbert, C Dalban… - European Journal of …, 2021 - Elsevier
Introduction Multikinase inhibitor (MKI) treatments have shown efficacy in progressive
radioiodine refractory thyroid cancers (RAIR-TC), but most patients experienced substantial …

Feasibility of apatinib in radioiodine-refractory differentiated thyroid carcinoma

W Du, X Shi, Q Fang, X Zhang, S Liu - Frontiers in Endocrinology, 2022 - frontiersin.org
Objectives Our aim was to describe our experience in using apatinib as treatment for
radioiodine-refractory differentiated thyroid carcinoma (RAIR-DTC). Methods Forty-seven …

Antitumour effects of apatinib in progressive, metastatic differentiated thyroid cancer (DTC)

L Shi, Q You, J Wang, H Wang, S Li, R Tian, X Yao… - Endocrine, 2022 - Springer
Purpose Management of progressive, metastatic radioactive iodine refractory differentiated
thyroid cancer (RAIR-DTC) has been a great challenge due to its poor prognosis and limited …