The challenging severity of some infections, especially in critically ill patients, makes the
diffusion of antimicrobial drugs within tissues one of the cornerstones of chemotherapy. The …

Critically ill patients admitted to intensive care unit (ICU) with severe infections, or those who
develop nosocomial infections, have poor outcomes with substantial morbidity and mortality …

Rationale: Data suggest that altered antimicrobial concentrations are likely during
extracorporeal membrane oxygenation (ECMO). Objectives: The primary aim of this analysis …

Antimicrobial resistance is considered one of the major threats to public health and is an
important factor that influences the patient's outcome in the intensive care unit …

Piperacillin-tazobactam is a potent β-lactam/β-lactamase inhibitor antibiotic commonly
prescribed in the intensive care unit setting. Admitted patients often show large variability in …

Objectives Knowledge on the tissue penetration of piperacillin-tazobactam in children with
sepsis is lacking. In this study, the feasibility and performance of microdialysis experiments …

What is known and objective Timely and appropriate dosing of antibiotics is essential for the
treatment of bacterial sepsis. Critically ill patients treated with continuous kidney …

Abstract Background and Objective Piperacillin is a broad-spectrum β-lactam antibiotic
commonly prescribed in intensive care units. Many piperacillin population pharmacokinetic …

Objectives To explore extracorporeal membrane oxygenation (ECMO)-related alterations of
the pharmacokinetics (PK) of piperacillin/tazobactam and determine an optimal dosage …

Introduction Older individuals face an elevated risk of developing bacterial infections. The
optimal use of antibacterial agents in this population is challenging because of age-related …