Oxidative stress as a common key event in developmental neurotoxicity
Y Nishimura, Y Kanda, H Sone… - Oxidative medicine and …, 2021 - Wiley Online Library
The developing brain is extremely sensitive to many chemicals. Perinatal exposure to
neurotoxicants has been implicated in several neurodevelopmental disorders, including …
neurotoxicants has been implicated in several neurodevelopmental disorders, including …
Stem cells based in vitro models: trends and prospects in biomaterials cytotoxicity studies
Advanced biomaterials are increasingly used for numerous medical applications from the
delivery of cancer-targeted therapeutics to the treatment of cardiovascular diseases. The …
delivery of cancer-targeted therapeutics to the treatment of cardiovascular diseases. The …
[HTML][HTML] Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures
F Pistollato, D Carpi, E Mendoza-de Gyves… - Reproductive …, 2021 - Elsevier
Prenatal and postnatal co-exposure to multiple chemicals at the same time may have
deleterious effects on the developing nervous system. We previously showed that chemicals …
deleterious effects on the developing nervous system. We previously showed that chemicals …
Modelling human variability in toxicokinetic and toxicodynamic processes using Bayesian meta‐analysis, physiologically‐based modelling and in vitro systems
E Testai, C Bechaux, FM Buratti… - EFSA Supporting …, 2021 - Wiley Online Library
This external scientific report summarises the results from thearticle 36 grant
GA/EFSA/SCER/2015/01 ″Modelling human variability in toxicokinetic and toxicodynamic …
GA/EFSA/SCER/2015/01 ″Modelling human variability in toxicokinetic and toxicodynamic …
Diazinon pesticide photocatalytic degradation in aqueous matrices based on reductive agent release in iodide exciting under UV Irradiation
H Azarpira, T Rasolevandi, AH Mahvi… - … Science and Pollution …, 2022 - Springer
Regarding the cost-effective degradation of diazinon (DIZ), the present study was conducted
to develop and UV/iodide process in a photo catalyst reactor. CCD modeling applied and …
to develop and UV/iodide process in a photo catalyst reactor. CCD modeling applied and …
Vesicular glutamate release from feeder-freehiPSC-derived neurons
Human-induced pluripotent stem cells (hiPSCs) represent one of the main and powerful
tools for the in vitro modeling of neurological diseases. Standard hiPSC-based protocols …
tools for the in vitro modeling of neurological diseases. Standard hiPSC-based protocols …
[HTML][HTML] Developmental neurotoxicity of acrylamide and its metabolite glycidamide in a human mixed culture of neurons and astrocytes undergoing differentiation in …
Neural stem cells (NSCs) derived from human induced pluripotent stem cells were used to
investigate effects of exposure to the food contaminant acrylamide (AA) and its main …
investigate effects of exposure to the food contaminant acrylamide (AA) and its main …
Methodological approaches for risk assessment of tobacco and related products
YCM Staal, PMJ Bos, R Talhout - Toxics, 2022 - mdpi.com
Health risk assessment of tobacco and related products (TRPs) is highly challenging due to
the variety in products, even within the product class, the complex mixture of components in …
the variety in products, even within the product class, the complex mixture of components in …
A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides
K Bartmann, F Bendt, A Dönmez, D Haag, E Keßel… - bioRxiv, 2023 - biorxiv.org
Proper brain development is based on the orchestration of key neurodevelopmental
processes, including the formation and function of neural networks. If at least one key …
processes, including the formation and function of neural networks. If at least one key …
Upscaling biological complexity to boost neuronal and oligodendroglia maturation and improve in vitro developmental neurotoxicity (DNT) evaluation
C Nunes, G Gorczyca, E Mendoza-deGyves… - Reproductive …, 2022 - Elsevier
Human induced pluripotent stem cell (iPSC)-derived neuronal and glial cell models are
suitable to assess the effects of environmental chemicals on the developing brain. Such test …
suitable to assess the effects of environmental chemicals on the developing brain. Such test …