Oxidative stress as a common key event in developmental neurotoxicity

Y Nishimura, Y Kanda, H Sone… - Oxidative medicine and …, 2021 - Wiley Online Library
The developing brain is extremely sensitive to many chemicals. Perinatal exposure to
neurotoxicants has been implicated in several neurodevelopmental disorders, including …

Stem cells based in vitro models: trends and prospects in biomaterials cytotoxicity studies

U Ahmed, R Ahmed, MS Masoud, M Tariq… - Biomedical …, 2021 - iopscience.iop.org
Advanced biomaterials are increasingly used for numerous medical applications from the
delivery of cancer-targeted therapeutics to the treatment of cardiovascular diseases. The …

[HTML][HTML] Combining in vitro assays and mathematical modelling to study developmental neurotoxicity induced by chemical mixtures

F Pistollato, D Carpi, E Mendoza-de Gyves… - Reproductive …, 2021 - Elsevier
Prenatal and postnatal co-exposure to multiple chemicals at the same time may have
deleterious effects on the developing nervous system. We previously showed that chemicals …

Modelling human variability in toxicokinetic and toxicodynamic processes using Bayesian meta‐analysis, physiologically‐based modelling and in vitro systems

E Testai, C Bechaux, FM Buratti… - EFSA Supporting …, 2021 - Wiley Online Library
This external scientific report summarises the results from thearticle 36 grant
GA/EFSA/SCER/2015/01 ″Modelling human variability in toxicokinetic and toxicodynamic …

Diazinon pesticide photocatalytic degradation in aqueous matrices based on reductive agent release in iodide exciting under UV Irradiation

H Azarpira, T Rasolevandi, AH Mahvi… - … Science and Pollution …, 2022 - Springer
Regarding the cost-effective degradation of diazinon (DIZ), the present study was conducted
to develop and UV/iodide process in a photo catalyst reactor. CCD modeling applied and …

Vesicular glutamate release from feeder-freehiPSC-derived neurons

S Baldassari, C Cervetto, S Amato, F Fruscione… - International Journal of …, 2022 - mdpi.com
Human-induced pluripotent stem cells (hiPSCs) represent one of the main and powerful
tools for the in vitro modeling of neurological diseases. Standard hiPSC-based protocols …

[HTML][HTML] Developmental neurotoxicity of acrylamide and its metabolite glycidamide in a human mixed culture of neurons and astrocytes undergoing differentiation in …

AJ Lauvås, M Lislien, JA Holme, H Dirven, RE Paulsen… - Neurotoxicology, 2022 - Elsevier
Neural stem cells (NSCs) derived from human induced pluripotent stem cells were used to
investigate effects of exposure to the food contaminant acrylamide (AA) and its main …

Methodological approaches for risk assessment of tobacco and related products

YCM Staal, PMJ Bos, R Talhout - Toxics, 2022 - mdpi.com
Health risk assessment of tobacco and related products (TRPs) is highly challenging due to
the variety in products, even within the product class, the complex mixture of components in …

A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides

K Bartmann, F Bendt, A Dönmez, D Haag, E Keßel… - bioRxiv, 2023 - biorxiv.org
Proper brain development is based on the orchestration of key neurodevelopmental
processes, including the formation and function of neural networks. If at least one key …

Upscaling biological complexity to boost neuronal and oligodendroglia maturation and improve in vitro developmental neurotoxicity (DNT) evaluation

C Nunes, G Gorczyca, E Mendoza-deGyves… - Reproductive …, 2022 - Elsevier
Human induced pluripotent stem cell (iPSC)-derived neuronal and glial cell models are
suitable to assess the effects of environmental chemicals on the developing brain. Such test …